School of Nursing, Hangzhou Normal University, Zhejiang 310015, China.
School of Public Health, Hangzhou Normal University, Zhejiang 310015, China.
Endocr J. 2023 Oct 30;70(10):959-967. doi: 10.1507/endocrj.EJ23-0157. Epub 2023 Jul 20.
An association exists between nonalcoholic fatty liver disease (NAFLD) and growth hormone (GH). Patients with growth hormone deficiency (GHD) may be more susceptible to NAFLD. The prevalence of NAFLD and nonalcoholic steatohepatitis (NASH) in GHD patients is currently unknown. Multiple databases were searched for experiments related to NAFLD (or NASH) and GHD. Screening, quality evaluation and data extraction were carried out independently by two authors. Analyses used random or fixed effects models, including NAFLD prevalence, NASH prevalence, odds ratio (OR) and 95% confidence interval (CI). We included 10 studies with a total of 782 participants. The results showed that the prevalence of NAFLD in GHD patients was 51% (95% CI: 39-63). The risk of NAFLD in GHD patients was significantly higher than that in controls (age-, sex- or body mass index-matched, without GHD) (pooled OR = 4.27, 95% CI: 1.33-13.68%, p = 0.015). The prevalence of NASH in GHD patients was 18% (95% CI: 5-31). The prevalence of NAFLD in GHD patients is significantly higher than that in the general population, especially NASH. There is a need to develop targeted strategies for the early identification, prevention, or control of NAFLD/NASH in patients with GHD.
非酒精性脂肪性肝病 (NAFLD) 与生长激素 (GH) 之间存在关联。生长激素缺乏症 (GHD) 患者可能更容易患 NAFLD。目前尚不清楚 GHD 患者中 NAFLD 和非酒精性脂肪性肝炎 (NASH) 的患病率。多个数据库被搜索与 NAFLD（或 NASH）和 GHD 相关的实验。两名作者独立进行筛选、质量评估和数据提取。分析使用随机或固定效应模型，包括 NAFLD 患病率、NASH 患病率、比值比 (OR) 和 95%置信区间 (CI)。我们纳入了 10 项共 782 名参与者的研究。结果表明，GHD 患者的 NAFLD 患病率为 51%（95%CI：39-63）。GHD 患者发生 NAFLD 的风险明显高于对照组（年龄、性别或体重指数匹配，无 GHD）（汇总 OR=4.27，95%CI：1.33-13.68%，p=0.015）。GHD 患者 NASH 的患病率为 18%（95%CI：5-31）。GHD 患者的 NAFLD 患病率明显高于普通人群，尤其是 NASH。需要制定针对 GHD 患者的早期识别、预防或控制 NAFLD/NASH 的针对性策略。
