Development, Disease Models, and Therapeutics Graduate Program, Baylor College of Medicine. Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA; Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Departments of Molecular and Human Genetics and Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Center for Precision Environmental Health, Department of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Trends Endocrinol Metab. 2023 Sep;34(9):539-553. doi: 10.1016/j.tem.2023.06.005. Epub 2023 Jul 17.
Changes in maternal nutrient availability due to diet or disease significantly increase the risk of neural tube defects (NTDs). Because the incidence of metabolic disease continues to rise, it is urgent that we better understand how altered maternal nutrient levels can influence embryonic neural tube development. Furthermore, primary neurulation occurs before placental function during a period of histiotrophic nutrient exchange. In this review we detail how maternal metabolites are transported by the yolk sac to the developing embryo. We discuss recent advances in understanding how altered maternal levels of essential nutrients disrupt development of the neuroepithelium, and identify points of intersection between metabolic pathways that are crucial for NTD prevention.
由于饮食或疾病导致的母体营养供应变化会显著增加神经管缺陷（NTDs）的风险。由于代谢性疾病的发病率持续上升，因此我们迫切需要更好地了解母体营养水平的变化如何影响胚胎神经管的发育。此外，初级神经胚发生发生在胎盘功能之前，此时是组织营养交换的时期。在这篇综述中，我们详细介绍了母体代谢物如何通过卵黄囊转运到发育中的胚胎。我们讨论了最近在理解母体必需营养素水平改变如何破坏神经上皮发育方面的进展，并确定了对 NTD 预防至关重要的代谢途径的交叉点。
