School of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.
School of Mathematics and Statistics, Wellington Faculty of Engineering, Victoria University of Wellington, Wellington, New Zealand.
Nat Commun. 2023 Jul 19;14(1):4330. doi: 10.1038/s41467-023-39595-y.
In Aotearoa New Zealand, zoster vaccine live is used for the prevention of zoster and associated complications in adults. This study assessed the risk of pre-specified serious adverse events following zoster vaccine live immunisation among adults in routine clinical practice. We conducted a self-controlled case series study using routinely collected national data. We compared the incidence of serious adverse events during the at-risk period with the control period. Rate ratios were estimated using Conditional Poisson regression models. Falsification outcomes analyses were used to evaluate biases in our study population. From April 2018 to July 2021, 278,375 received the vaccine. The rate ratio of serious adverse events following immunisation was 0·43 (95% confidence interval [CI]: 0·37-0·50). There was no significant increase in the risk of cerebrovascular accidents, acute myocardial infarction, acute pericarditis, acute myocarditis, and Ramsay-Hunt Syndrome. The herpes zoster vaccine is safe in adults in Aotearoa New Zealand.
在新西兰，带状疱疹活疫苗被用于预防成人带状疱疹及相关并发症。本研究评估了在常规临床实践中，带状疱疹活疫苗免疫接种后预先指定的严重不良事件的风险。我们使用常规收集的全国数据开展了一项自身对照病例系列研究。我们比较了风险期和对照期内严重不良事件的发生率。使用条件泊松回归模型估计了率比。我们使用虚假结局分析来评估研究人群中的偏倚。2018 年 4 月至 2021 年 7 月，有 278375 人接种了疫苗。接种后严重不良事件的发生率比为 0.43（95%置信区间[CI]：0.37-0.50）。接种疫苗后，脑血管意外、急性心肌梗死、急性心包炎、急性心肌炎和 Ramsay-Hunt 综合征的风险没有显著增加。带状疱疹疫苗在新西兰成年人中是安全的。
