长链非编码RNA-LRRTM4通过激活LRRTM4转录促进结直肠癌的增殖、转移和上皮-间质转化。

Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription.

作者信息

Zhang Jingjie, Meng Xianmei, Zhou Yi, Jiang Zhengyu, Chen Hongsuo, Meng Zhiyi, Zhang Qi, Chen Weichang

机构信息

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, P. R. China.

Center of Digestive Endoscopy, The Second Affiliated Hospital of Baotou Medical College, Baotou, 014000, Inner Mongolia, China.

出版信息

Cancer Cell Int. 2023 Jul 19;23(1):142. doi: 10.1186/s12935-023-02986-8.

DOI:10.1186/s12935-023-02986-8

PMID:37468908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357798/

Abstract

Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC.

摘要

众多机制已表明长链非编码RNA（lncRNAs）促进结直肠癌（CRC）的发展，但lnc-LRRTM4在CRC进展中的作用仍不清楚。在本文中，我们发现lnc-LRRTM4在CRC组织和细胞系中高表达，且lnc-LRRTM4可促进CRC细胞的增殖和转移。这些结果是通过lnc-LRRTM4直接结合LRRTM4的启动子以诱导其转录而实现的。此外，lnc-LRRTM4通过促进细胞周期进程和减少细胞凋亡来增强CRC细胞在体内的生长。综上所述，我们的结果表明lnc-LRRTM4促进CRC细胞的增殖和转移，提示它可能是CRC潜在的诊断和治疗靶点。