• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment.长链非编码RNA lnc-sox5通过失衡肿瘤微环境来调节结直肠癌的肿瘤发生。
Cell Cycle. 2017 Jul 3;16(13):1295-1301. doi: 10.1080/15384101.2017.1317416. Epub 2017 Jun 20.
2
HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis.HuR通过稳定lnc-Sox5信使核糖核酸促进舌癌发生。
Biochemistry (Mosc). 2017 Apr;82(4):438-445. doi: 10.1134/S0006297917040046.
3
LncRna CPS1-IT1 Suppresses Cell Proliferation, Invasion and Metastasis in Colorectal Cancer.长链非编码RNA CPS1-IT1抑制结直肠癌的细胞增殖、侵袭和转移。
Cell Physiol Biochem. 2017;44(2):567-580. doi: 10.1159/000485091. Epub 2017 Nov 17.
4
Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer.长链非编码RNA FOXP4-AS1是一种不良预后因素，可调节结直肠癌的增殖和凋亡。
Cell Prolif. 2017 Feb;50(1). doi: 10.1111/cpr.12312. Epub 2016 Oct 27.
5
A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit.一种新型长链非编码RNA lnc-GNAT1-1在结直肠癌中低表达，并通过调节RKIP-NF-κB-Snail信号通路发挥肿瘤抑制作用。
J Exp Clin Cancer Res. 2016 Dec 3;35(1):187. doi: 10.1186/s13046-016-0467-z.
6
A novel lncRNA SOX2OT promotes the malignancy of human colorectal cancer by interacting with miR-194-5p/SOX5 axis.一种新型长链非编码 RNA SOX2OT 通过与 miR-194-5p/SOX5 轴相互作用促进人类结直肠癌的恶性转化。
Cell Death Dis. 2021 May 15;12(5):499. doi: 10.1038/s41419-021-03756-y.
7
Long non-coding RNA Lnc-LALC facilitates colorectal cancer liver metastasis via epigenetically silencing LZTS1.长链非编码 RNA Lnc-LALC 通过表观遗传沉默 LZTS1 促进结直肠癌肝转移。
Cell Death Dis. 2021 Feb 26;12(2):224. doi: 10.1038/s41419-021-03461-w.
8
Long non-coding RNA AFAP1-AS1 facilitates tumor growth and promotes metastasis in colorectal cancer.长链非编码RNA AFAP1-AS1促进结直肠癌的肿瘤生长并促进转移。
Biol Res. 2016 Aug 30;49(1):36. doi: 10.1186/s40659-016-0094-3.
9
Long non-coding RNA DILC suppresses cell proliferation and metastasis in colorectal cancer.长非编码 RNA DILC 抑制结直肠癌细胞增殖和转移。
Gene. 2018 Aug 5;666:18-26. doi: 10.1016/j.gene.2018.03.100. Epub 2018 Apr 3.
10
LINC00707 promotes cell proliferation and invasion of colorectal cancer via miR-206/FMNL2 axis.LINC00707 通过 miR-206/FMNL2 轴促进结直肠癌细胞增殖和侵袭。
Eur Rev Med Pharmacol Sci. 2019 May;23(9):3749-3759. doi: 10.26355/eurrev_201905_17801.

引用本文的文献

1
Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer.长链非编码RNA在免疫逃逸中的功能、机制及其在结直肠癌免疫治疗中的应用
J Transl Med. 2025 Jun 19;23(1):689. doi: 10.1186/s12967-025-06732-8.
2
SOX5 inhibition overcomes PARP inhibitor resistance in BRCA-mutated breast and ovarian cancer.SOX5抑制可克服BRCA突变的乳腺癌和卵巢癌中的PARP抑制剂耐药性。
Cell Death Dis. 2025 Apr 24;16(1):333. doi: 10.1038/s41419-025-07660-7.
3
Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy.非编码RNA与结直肠癌程序性细胞死亡之间的相互作用：对靶向治疗的启示
Epigenetics Chromatin. 2025 Jan 15;18(1):3. doi: 10.1186/s13072-024-00560-8.
4
The role of HOTAIR in the modulation of resistance to anticancer therapy.HOTAIR在调节抗癌治疗耐药性中的作用。
Front Mol Biosci. 2024 Jun 3;11:1414651. doi: 10.3389/fmolb.2024.1414651. eCollection 2024.
5
Downregulated PDIA3P1 lncRNA Impairs Trophoblast Phenotype by Regulating Snail and SFRP1 in PE.下调的 PDIA3P1 lncRNA 通过调节 PE 中的 Snail 和 SFRP1 损害滋养层表型。
Anal Cell Pathol (Amst). 2024 Apr 27;2024:8972022. doi: 10.1155/2024/8972022. eCollection 2024.
6
HBCR_DMR: A Hybrid Method Based on Beta-Binomial Bayesian Hierarchical Model and Combination of Ranking Method to Detect Differential Methylation Regions in Bisulfite Sequencing Data.HBCR_DMR：一种基于贝塔-二项式贝叶斯分层模型和排序方法组合的混合方法，用于检测亚硫酸氢盐测序数据中的差异甲基化区域。
J Pers Med. 2024 Mar 29;14(4):361. doi: 10.3390/jpm14040361.
7
Exploring the regulatory role of lncRNA in cancer immunity.探索长链非编码RNA在癌症免疫中的调控作用。
Front Oncol. 2023 Aug 10;13:1191913. doi: 10.3389/fonc.2023.1191913. eCollection 2023.
8
Regulation of T cell differentiation and function by long noncoding RNAs in homeostasis and cancer.长非编码 RNA 对 T 细胞分化和功能的调控及其在稳态和癌症中的作用。
Front Immunol. 2023 Jun 6;14:1181499. doi: 10.3389/fimmu.2023.1181499. eCollection 2023.
9
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets.肿瘤微环境中的表观遗传调控：分子机制和治疗靶点。
Signal Transduct Target Ther. 2023 May 22;8(1):210. doi: 10.1038/s41392-023-01480-x.
10
The regulatory role of long non- coding RNAs as a novel controller of immune response against cancer cells.长非编码 RNA 作为一种新型的癌细胞免疫反应调控因子的调控作用。
Mol Biol Rep. 2022 Dec;49(12):11775-11793. doi: 10.1007/s11033-022-07947-4. Epub 2022 Oct 7.

本文引用的文献

1
RNA. A lncRNA links genomic variation with celiac disease.核糖核酸。一种长链非编码核糖核酸将基因组变异与乳糜泻联系起来。
Science. 2016 Apr 1;352(6281):43-4. doi: 10.1126/science.aaf6015. Epub 2016 Mar 31.
2
Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.长链非编码RNA H19提示结直肠癌预后不良，并通过招募和结合eIF4A3促进肿瘤生长。
Oncotarget. 2016 Apr 19;7(16):22159-73. doi: 10.18632/oncotarget.8063.
3
Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma.联合检测血清中长链非编码RNA CCAT1和HOTAIR作为结直肠癌的有效筛查方法
Int J Clin Exp Pathol. 2015 Nov 1;8(11):14131-40. eCollection 2015.
4
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.CCAT1是一种增强子模板化RNA，可预测结直肠癌对BET蛋白的敏感性。
J Clin Invest. 2016 Feb;126(2):639-52. doi: 10.1172/JCI83265. Epub 2016 Jan 11.
5
Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance.长链非编码RNA-CCAT1、E-钙黏蛋白和N-钙黏蛋白在结直肠癌中的表达及其临床意义。
Int J Clin Exp Med. 2015 Mar 15;8(3):3707-15. eCollection 2015.
6
[A case of colorectal cancer with pelvic recurrence treated by systemic chemotherapy and radiotherapy].
Gan To Kagaku Ryoho. 2014 Nov;41(12):1719-21.
7
Global cancer statistics, 2012.全球癌症统计数据，2012 年。
CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4.
8
Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial.术前（放）化疗和全直肠系膜切除术治疗的直肠癌患者的辅助化疗：荷兰结直肠肿瘤学组（DCCG）的一项随机 III 期试验。
Ann Oncol. 2015 Apr;26(4):696-701. doi: 10.1093/annonc/mdu560. Epub 2014 Dec 5.
9
Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus.人类结直肠癌细胞特异性 CCAT1-L lncRNA 调节 MYC 基因座的长程染色质相互作用。
Cell Res. 2014 May;24(5):513-31. doi: 10.1038/cr.2014.35. Epub 2014 Mar 25.
10
Innate and adaptive immune cells in the tumor microenvironment.肿瘤微环境中的固有和适应性免疫细胞。
Nat Immunol. 2013 Oct;14(10):1014-22. doi: 10.1038/ni.2703.

长链非编码RNA lnc-sox5通过失衡肿瘤微环境来调节结直肠癌的肿瘤发生。

Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment.

作者信息

Wu Kaiming, Zhao Zhenxian, Liu Kuanzhi, Zhang Jian, Li Guanghua, Wang Liang

机构信息

a Gastrointestinal Surgery Center , 1st Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , P.R. China.

b Department of Pancreato-Biliary Surgery , 1st Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , P.R. China.

出版信息

Cell Cycle. 2017 Jul 3;16(13):1295-1301. doi: 10.1080/15384101.2017.1317416. Epub 2017 Jun 20.

DOI:10.1080/15384101.2017.1317416
PMID:28632999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5531622/
Abstract

Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3CD8T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.

摘要

长链非编码RNA（LncRNAs）最近被认为是包括肿瘤发生在内的多种生物学过程中的系统性调节因子。在本研究中，我们观察到lncRNA lnc-sox5在结直肠癌（CRC）中的表达显著增加。尽管lnc-sox5敲低不影响CRC细胞的生长、细胞周期和细胞凋亡，但lnc-sox5敲低抑制了CRC细胞的迁移和侵袭。此外，异种移植动物模型表明，lnc-sox5敲低显著抑制了CRC的肿瘤发生。我们的结果还表明，lnc-sox5敲低显著降低了吲哚胺2,3-双加氧酶1（IDO1）的表达，从而调节了CD3CD8T细胞的浸润和细胞毒性。综上所述，这些结果表明lnc-sox5通过失衡肿瘤微环境来调节结直肠癌的进展。