长链非编码RNA lnc-sox5通过失衡肿瘤微环境来调节结直肠癌的肿瘤发生。
Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment.
作者信息
Wu Kaiming, Zhao Zhenxian, Liu Kuanzhi, Zhang Jian, Li Guanghua, Wang Liang
机构信息
a Gastrointestinal Surgery Center , 1st Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , P.R. China.
b Department of Pancreato-Biliary Surgery , 1st Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , P.R. China.
出版信息
Cell Cycle. 2017 Jul 3;16(13):1295-1301. doi: 10.1080/15384101.2017.1317416. Epub 2017 Jun 20.
Abstract
Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3CD8T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.
摘要
长链非编码RNA（LncRNAs）最近被认为是包括肿瘤发生在内的多种生物学过程中的系统性调节因子。在本研究中，我们观察到lncRNA lnc-sox5在结直肠癌（CRC）中的表达显著增加。尽管lnc-sox5敲低不影响CRC细胞的生长、细胞周期和细胞凋亡，但lnc-sox5敲低抑制了CRC细胞的迁移和侵袭。此外，异种移植动物模型表明，lnc-sox5敲低显著抑制了CRC的肿瘤发生。我们的结果还表明，lnc-sox5敲低显著降低了吲哚胺2,3-双加氧酶1（IDO1）的表达，从而调节了CD3CD8T细胞的浸润和细胞毒性。综上所述，这些结果表明lnc-sox5通过失衡肿瘤微环境来调节结直肠癌的进展。
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