联合辅酶 Q10 和枸橼酸氯米酚与单独使用枸橼酸氯米酚对多囊卵巢综合征患者促排卵的比较研究。

Comparative Study Of Combined Co-Enzyme Q10 And Clomiphene Citrate Vs Clomiphene Citrate Alone For Ovulation Induction In Patients With Polycystic Ovarian Syndrome.

机构信息

Department of Obstetrics and Gynecology, King Edward Medical University, Lady Atchison Hospital, Lahore, Pakistan.

Department of General Surgery, King Edward Medical University, Mayo Hospital, Lahore, Pakistan.

出版信息

J Pak Med Assoc. 2023 Jul;73(7):1502-1505. doi: 10.47391/JPMA.7299.

DOI:10.47391/JPMA.7299

PMID:37469067

Abstract

A total of 136 patients with PCOS were followed through the Department of the Obstetrics and Gynaecology, Unit-IV, Lady Aitchison Hospital, Lahore. Patients were randomly divided by lottery method into two groups i.e., Group-A (CoQ10 plus Clomiphene citrate) and Group-B (Clomiphene citrate alone). The selected patients in the study group (group-A) were given Clomiphene citrate 100mg/day from cycle days 2-6 for 45 days (2 cycles) and CoQ10 in a dose of 50mg soft gel capsules thrice per day starting at cycle day-2, until HCG administration. Patients in controlled group (group 21 B) received Clomiphene citrate 100mg/day twice a day cycle for 45 days. Data were analysed in SPSS v25.0. In group-A (CoQ10 plus Clomiphene citrate), successful ovulation induction was noted in 16 (23.5%) patients, showing that with the addition of CoQ10, the chances of ovulation induction increased.

摘要

共有 136 名多囊卵巢综合征患者在拉合尔艾奇逊夫人医院妇产科 IV 科接受随访。患者通过抽签方法随机分为两组，即 A 组（辅酶 Q10 加克罗米酚）和 B 组（单独使用克罗米酚）。研究组（A 组）的选定患者给予克罗米酚 100mg/天，从周期第 2-6 天，共 45 天（2 个周期），从周期第 2 天开始，每天服用 3 次 50mg 软胶囊辅酶 Q10，直至 HCG 给药。对照组（B 组 21）患者每天两次接受克罗米酚 100mg/天，共 45 天。数据在 SPSS v25.0 中进行分析。在 A 组（辅酶 Q10 加克罗米酚）中，16 名（23.5%）患者成功诱导排卵，表明添加辅酶 Q10 可增加排卵诱导的机会。