Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Electrical and Computer Engineering, University of Western Macedonia, Kozani, Greece.
Ther Apher Dial. 2024 Feb;28(1):9-22. doi: 10.1111/1744-9987.14037. Epub 2023 Jul 19.
Hospitalization for decompensated heart failure is a major public health issue.
We performed a meta-analysis to summarize and analyze if there is a benefit in using ultrafiltration over diuretics in terms of reducing mortality or hospital readmissions, primarily and identified 10 randomized controlled trials (RCTs) including 941 patients.
Compared to diuretics, treatment with ultrafiltration was associated with a significant reduction in heart failure hospitalizations (risk ratio [RR]: 0.72; 95% confidence interval [CI]: 0.55-0.96, p = 0.02) and significant increase in weight and net fluid loss (mean difference [MD]: -1.55, CI: -2.36 to -0.74, p = 0.0002) and (MD: -2.10, CI: -3.32 to -0.89, p = 0.0007), respectively. There was no significant difference among treatments regarding the duration of hospitalization, the increase in serum creatinine levels, and mortality.
Among patients with decompensated heart failure, compared to diuretics, ultrafiltration is associated with reduced rehospitalizations and increased weight/net fluid loss.
心力衰竭失代偿的住院治疗是一个主要的公共卫生问题。
我们进行了荟萃分析，以总结和分析在降低死亡率或再住院率方面，超滤是否优于利尿剂，主要确定了 10 项随机对照试验（RCT），包括 941 名患者。
与利尿剂相比，超滤治疗与心力衰竭住院率显著降低相关（风险比 [RR]：0.72；95%置信区间 [CI]：0.55-0.96，p=0.02），体重和净液体丢失显著增加（平均差异 [MD]：-1.55，CI：-2.36 至-0.74，p=0.0002）和（MD：-2.10，CI：-3.32 至-0.89，p=0.0007）。在住院时间、血清肌酐水平升高和死亡率方面，治疗之间没有显著差异。
在心力衰竭失代偿的患者中，与利尿剂相比，超滤与再住院率降低和体重/净液体丢失增加相关。
