Lo Kevin Bryan, Nohria Anju
Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Heart Fail Rev. 2025 Mar;30(2):417-430. doi: 10.1007/s10741-024-10473-z. Epub 2024 Dec 15.
Hospitalization for ADHF is linked to poor outcomes, with residual congestion at discharge significantly increasing the risk of HF readmissions and mortality. Diuretic resistance is a major contributor to inadequate decongestion during ADHF treatment. In this review, we discuss various decongestive strategies, emphasizing the management of diuretic resistance. Additionally, we examine the limitations of current decongestion trials and highlight key priorities for future research.
因急性失代偿性心力衰竭（ADHF）住院与不良预后相关，出院时仍有充血症状会显著增加心力衰竭再入院和死亡风险。利尿剂抵抗是ADHF治疗期间充血缓解不足的主要原因。在本综述中，我们讨论了各种充血缓解策略，重点是利尿剂抵抗的管理。此外，我们审视了当前充血缓解试验的局限性，并强调了未来研究的关键重点。
