Department of Periodontology, Faculty of Dentistry, Damascus, University, Damascus, Syria.
Department of Pediatric Dentistry, Faculty of Dentistry, Damascus, University, Damascus, Syria, Phone: +00963988812044, e-mail: yasseralsayedtolibah@gmail, Orcid: https://orcid.org/0000-0001-5498-9991.
J Contemp Dent Pract. 2023 Apr 1;24(4):214-220. doi: 10.5005/jp-journals-10024-3496.
This study aimed to evaluate the effect of injectable platelet-rich fibrin (i-PRF) as a potential catalyst for the acceleration of palatal wound healing after subepithelial connective tissue graft (SCTG) harvesting.
Referred patients to the Department of Periodontology with the complication of the gingival recession were examined. Thirty participants were chosen for root coverage surgeries with SCTGs, and randomly distributed into two groups; the study group ( = 15) with i-PRF was applied, and the control group ( = 15) without i-PRF. The wound healing index was evaluated on the 7th, 14th, and 30th days of the treatment. Palatal tissue thickness was measured before the treatment and at the 1st, 2nd, and 3rd months after the treatment.
The study group improved significantly the early healing over the control group on days 7 and 14 ( < 0.01), whereas no difference in the first month ( > 0.05) between the groups. Moreover, the study group showed higher tissue thickness mean in the first and second month ( < 0.01), but in the third month, there were no significant differences ( > 0.05) between both groups.
The i-PRF has favorable effects on the healing process by enhancing wound healing and increasing the tissue thickness in the palate after SCTG harvesting.
For clinicians, it is important to know that we can use biological materials to accelerate healing in general, such as i-PRF. In this study, we used it in the palate, which may accelerate the healing so that we can repeatedly use the same area of the patient's palate for more than one occasion faster.
本研究旨在评估注射用富血小板纤维蛋白（i-PRF）作为加速黏膜下结缔组织移植（SCTG）后腭部伤口愈合的潜在催化剂的效果。
将患有牙龈退缩并发症的患者转诊到牙周科进行检查。选择 30 名患者进行 SCTG 根覆盖手术，并随机分为两组；研究组（n=15）应用 i-PRF，对照组（n=15）不应用 i-PRF。在治疗的第 7、14 和 30 天评估伤口愈合指数。在治疗前和治疗后第 1、2 和 3 个月测量腭部组织厚度。
研究组在第 7 和 14 天的早期愈合明显优于对照组（<0.01），而在第 1 个月两组之间无差异（>0.05）。此外，研究组在第 1 个月和第 2 个月的组织厚度平均值较高（<0.01），但在第 3 个月两组之间无显著差异（>0.05）。
i-PRF 通过促进伤口愈合和增加 SCTG 后腭部组织厚度，对愈合过程有良好的影响。
对于临床医生来说，了解我们可以使用生物材料来加速一般的愈合过程是很重要的，例如 i-PRF。在本研究中，我们将其应用于腭部，这可能会加速愈合，从而使我们能够更快地在患者的腭部同一区域重复使用不止一次。
