Shirbhate Unnati, Bajaj Pavan, Wanjari Mayur, Patil Manoj
Department of Research and Development, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, India.
JMIR Res Protoc. 2025 Jan 23;14:e65137. doi: 10.2196/65137.
Injectable platelet-rich fibrin (i-PRF) has the capacity to release great amounts of several growth factors, as well as to stimulate increased fibroblast migration and the expression of collagen, transforming growth factor β, and platelet-derived growth factor. Consequently, i-PRF can be used as a bioactive agent to promote periodontal tissue regeneration.
We aim to compare and evaluate the effectiveness of i-PRF in periodontal tissue regeneration.
We will conduct an electronic search in the following databases: PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Scopus, and Web of Science. Papers will be restricted to those in English and to those that are randomized controlled trials comparing PRF or any other biomaterial with i-PRF for periodontal regeneration during dental treatment. The included papers in this review and the reference lists of pertinent reviews will be manually searched. The selection of studies, data extraction, and assessment will be carried out separately by 2 reviewers using the Risk of Bias 2 tool for the included research.
The success of i-PRF will be evaluated by comparing the mean difference in periodontal regeneration of soft and hard tissues in terms of gingival recession, probing pocket depth, clinical attachment level, bone gain, and gingival width. The combined effect size measurements and the associated 95% CIs will be estimated using a random-effects model. The synthesis or work for this systematic review started in October 2023 and will last until December 2025.
i-PRF may play a role in dentistry and could enhance soft and hard tissue regeneration.
PROSPERO CRD42023464250; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=464250.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/65137.
可注射富血小板纤维蛋白（i-PRF）能够释放大量多种生长因子，还能刺激成纤维细胞迁移增加以及胶原蛋白、转化生长因子β和血小板衍生生长因子的表达。因此，i-PRF可作为一种生物活性剂用于促进牙周组织再生。
我们旨在比较和评估i-PRF在牙周组织再生中的有效性。
我们将在以下数据库进行电子检索：PubMed、Cochrane图书馆、谷歌学术、语义学者、Scopus和科学网。论文将限于英文论文以及那些在牙科治疗期间比较PRF或任何其他生物材料与i-PRF用于牙周再生的随机对照试验。将手动检索本综述纳入的论文以及相关综述的参考文献列表。研究的选择、数据提取和评估将由2名评审员分别使用纳入研究的偏倚风险2工具进行。
将通过比较软组织和硬组织牙周再生的平均差异来评估i-PRF的成功率，这些差异涉及牙龈退缩、探诊深度、临床附着水平、骨增量和牙龈宽度。将使用随机效应模型估计合并效应量测量值及相关的95%置信区间。本系统综述的综合或工作于2023年10月开始，将持续到2025年12月。
i-PRF可能在牙科中发挥作用，并可促进软组织和硬组织再生。
PROSPERO CRD42023464250；https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=464250。
国际注册报告识别号（IRRID）：PRR1-10.2196/65137。
