慢性色氨酸负荷对新生大鼠脑内血清素（5-羟色胺）水平的影响。
Effects of chronic tryptophan loading on serotonin (5-HT) levels in neonatal rat brain.
作者信息
Mathura C B, Singh H H, Tizabi Y, Hughes J E, Flesher S A
出版信息
J Natl Med Assoc. 1986 Jul;78(7):645-7.
Several earlier studies reported that the acute administration of L-tryptophan to adult rats caused an increase in brain serotonin levels. This study describes the effects of chronic tryptophan loading on serotonin concentration levels in various regions of the neonatal rat brain. Rats were injected with tryptophan methyl ester hydrochloride (100 mg/kg), intraperitoneally, daily from day 4 to day 24 after birth, and sacrificed on days 8, 19, and 29 after first injection. The brains were immediately dissected into their component regions, and serotonin concentration levels were measured by a radioenzymatic method. Chronic tryptophan loading produced a significant (P < .05) decrease in serotonin levels in all the brain regions as compared with saline-treated controls, except the pons and medulla regions, which showed significant (P < .001) increase on day 8.
几项早期研究报告称，对成年大鼠急性给予L-色氨酸会导致脑血清素水平升高。本研究描述了慢性色氨酸负荷对新生大鼠脑不同区域血清素浓度水平的影响。从出生后第4天至第24天，每天给大鼠腹腔注射盐酸色氨酸甲酯（100 mg/kg），并在首次注射后的第8天、第19天和第29天处死大鼠。将大脑立即解剖成各个组成区域，并用放射酶法测量血清素浓度水平。与生理盐水处理的对照组相比，慢性色氨酸负荷使所有脑区的血清素水平显著降低（P <.05），但脑桥和延髓区域除外，这两个区域在第8天显示出显著升高（P <.001）。
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