He Lanying, Wang Jian, Wang Feng, Wang Lu, Liu Yinglin, Zhou Fanfan, Xu Fan
Department of Neurology, The Second People's Hospital of Chengdu, Chengdu, China.
Department of Public Health, Chengdu Medical College, Chengdu, Sichuan, China.
Front Psychiatry. 2023 Jul 4;14:1166273. doi: 10.3389/fpsyt.2023.1166273. eCollection 2023.
To investigate the associations between risk factors and depression symptoms in ischemic stroke (IS) survivors and the effect of IS survivors' depression status and functional outcomes on caregiver burden in Chengdu, China.
In this cross-sectional study, we recruited a convenience sample of patients with IS and paired caregivers living in Chengdu from February 2022 to May 2022. Depression symptoms were assessed using the 17-item Chinese Hamilton Depression Rating Scale, the social support of patients was assessed using the perceived social support scale (PSSS), caregiver burden was assessed using the Zarit burden interview (ZBI). Multivariable logistic regression analysis was used to analyze the data between risk factors and depression symptoms, and multiple linear regression models were constructed to examine the depression symptoms and functional outcomes of stroke survivors, and caregiver burden.
In total, 966 IS survivors and paired caregivers were included in this study. Among IS survivors, 35.51% (343/966) experienced depression. Age [adjusted odds ratio (aOR), 1.02; 95% confidence interval (CI), 1.00-1.04; = 0.036], the National Institutes of Health Stroke Scale (NIHSS) score (aOR, 1.57; 95% CI, 1.47-1.68; < 0.001), and PSSS score (aOR, 0.86; 95% CI, 0.84-0.89; < 0.001) were associated with an increased risk of depression. The NIHSS score ( = 2.57, < 0.001), patients' depression status ( = 2.54, < 0.001), duration of care ( = 0.359, = 0.006), and social support of caregivers ( = -0.894, = 0.038) were significantly associated with the ZBI score.
The PSSS score was a major risk factor for the development of depression in IS survivors, and patients' depression status and severe functional deficits had a negative impact on the ZBI score of the main caregivers. Social support can reduce the ZBI score.
探讨中国成都缺血性脑卒中（IS）幸存者的危险因素与抑郁症状之间的关联，以及IS幸存者的抑郁状态和功能结局对照顾者负担的影响。
在这项横断面研究中，我们于2022年2月至2022年5月从成都招募了一个IS患者及其配对照顾者的便利样本。使用17项汉密尔顿抑郁量表评估抑郁症状，使用领悟社会支持量表（PSSS）评估患者的社会支持，使用Zarit照顾负担访谈量表（ZBI）评估照顾者负担。采用多变量逻辑回归分析来分析危险因素与抑郁症状之间的数据，并构建多元线性回归模型来检验脑卒中幸存者的抑郁症状和功能结局以及照顾者负担。
本研究共纳入966名IS幸存者及其配对照顾者。在IS幸存者中，35.51%（343/966）经历了抑郁。年龄[调整后的优势比（aOR），1.02；95%置信区间（CI），1.00 - 1.04；P = 0.036]、美国国立卫生研究院卒中量表（NIHSS）评分（aOR，1.57；95% CI，1.47 - 1.68；P < 0.001）和PSSS评分（aOR，0.86；95% CI，0.84 - 0.89；P < 0.001）与抑郁风险增加相关。NIHSS评分（P = 2.57，P < 0.001）、患者的抑郁状态（P = 2.54，P < 0.001）、照顾时长（P = 0.359，P = 0.006）和照顾者的社会支持（P = -0.894，P = 0.038）与ZBI评分显著相关。
PSSS评分是IS幸存者发生抑郁的主要危险因素，患者的抑郁状态和严重的功能缺陷对主要照顾者的ZBI评分有负面影响。社会支持可降低ZBI评分。
