Zeng Zheng, Lu Yuanyuan, Zhang Fuquan, Zhang Jie, Zhang Wenjun, Luo Chunli, Guo Yuping, Yan Junfang, Yu Lang
Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Department of Radiation Oncology, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, People's Republic of China.
Cancer Manag Res. 2023 Jul 14;15:691-697. doi: 10.2147/CMAR.S416366. eCollection 2023.
Endometrial carcinoma (EC) is a common gynecological malignancy. Vaginal cuff brachytherapy (VBT) is an adjuvant treatment for EC. Since a single-channel cylinder sometimes delivers inadequate dose coverage to the vaginal apex, three-dimensional (3D) printing technology can be used to achieve satisfactory dose distribution. Here, we report the first case of an EC patient with Herlyn-Werner-Wunderlich syndrome (HWWS) treated with VBT using 3D-printed applicators.
Here, we present a case study of an endometrial cancer patient with HWWS who underwent surgery. During adjuvant radiotherapy, 3D-printed applicators were used in VBT. To accomplish the reconstruction of the source pathways on magnetic resonance imaging, catheters with copper sulfate were placed in two 3D-printed applicators. The early tolerance of this treatment was positive. During the 6-month follow-up, locoregional recurrence was not detected.
Our findings strongly indicate that VBT with 3D-printed applicators may be a reasonable treatment option for EC with HWWS.
子宫内膜癌（EC）是一种常见的妇科恶性肿瘤。阴道残端近距离放射治疗（VBT）是EC的一种辅助治疗方法。由于单通道圆柱体有时无法为阴道顶端提供足够的剂量覆盖，三维（3D）打印技术可用于实现满意的剂量分布。在此，我们报告首例使用3D打印施源器进行VBT治疗的患有赫林-韦纳-温德利希综合征（HWWS）的EC患者。
在此，我们展示了一例患有HWWS的子宫内膜癌患者接受手术的病例研究。在辅助放疗期间，VBT中使用了3D打印施源器。为了在磁共振成像上完成源路径的重建，将含有硫酸铜的导管放置在两个3D打印施源器中。该治疗的早期耐受性良好。在6个月的随访期间，未检测到局部区域复发。
我们的研究结果有力地表明，使用3D打印施源器的VBT可能是患有HWWS的EC的一种合理治疗选择。
