Yang Jing, Chen Xiaowen, Li Xiaofang, Liu Wenci, Liao Sihai, Wang Yuzhou, Zuo Yufang
Department of Gynecological Oncology, Cancer Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Department of Pathology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Front Oncol. 2023 Jul 4;13:1198765. doi: 10.3389/fonc.2023.1198765. eCollection 2023.
Primary osteosarcoma of the uterus is an extremely rare pure heterologous sarcoma of the uterus. The relevant available information is limited to case reports. To date, only 31 cases of this type of cancer have been reported. Here, we report the first clinical experience with the administration of an immunotherapy-based combination regimen for multiple metastatic primary osteosarcomas of the uterus. The patient had undergone multiple treatments prior to this regimen, but her condition continued to progress. However, after 3 cycles of immunotherapy combined with targeted therapy and chemotherapy, a review showed that the disease was stable and even in partial remission. The patient has a good quality of life, and long-term survival is expected.
子宫原发性骨肉瘤是一种极其罕见的子宫纯异源性肉瘤。现有的相关信息仅限于病例报告。迄今为止，仅报道过31例此类癌症。在此，我们报告首例针对子宫多发性转移性原发性骨肉瘤采用基于免疫疗法的联合方案的临床经验。该患者在采用此方案之前已接受过多种治疗，但其病情仍持续进展。然而，在进行3个周期的免疫疗法联合靶向治疗和化疗后，复查显示病情稳定，甚至部分缓解。患者生活质量良好，有望长期生存。
