Du Val G, Grubb B R, Bentley P J
J Toxicol Environ Health. 1986;19(1):97-104. doi: 10.1080/15287398609530910.
The purpose of our investigation was to determine blood and tissue levels of aluminum (Al) in normal young rabbits. Furthermore, we wished to determine tissue distribution and accumulation of Al as related to its blood concentration in Al-dosed rabbits. The levels of Al accumulated were determined in different tissues of growing rabbits after continuous subcutaneous administration of Al chloride (3.78 mg/d) for 28 d. No signs of toxicity were apparent from comparisons of hematocrit or weight gain between control and Al-dosed rabbits. The largest concentration of the Al was observed in bone, which was also found to have the highest levels in the control rabbit tissues. Following bone, the experimental animals showed the greatest increase of Al levels in kidney cortex, kidney medulla, liver, testes, skeletal muscle, heart, brain white matter, and brain hippocampus, in that order. No significant difference was found in brain grey matter between control and experimental animals. As the brain tissue of the Al-treated animals had the lowest Al level of the tissues measured, it appears that there is a partial blood-brain barrier to entry of Al.
我们研究的目的是测定正常幼兔血液和组织中的铝（Al）含量。此外，我们希望确定在给铝的兔子中，铝的组织分布和蓄积情况与其血液浓度的关系。在生长中的兔子连续皮下注射氯化铝（3.78毫克/天）28天后，测定其不同组织中蓄积的铝含量。通过比较对照兔和给铝兔的血细胞比容或体重增加情况，未发现明显的毒性迹象。在骨骼中观察到铝的浓度最高，在对照兔组织中骨骼中的铝含量也最高。其次，实验动物的肾皮质、肾髓质、肝脏、睾丸、骨骼肌、心脏、脑白质和脑海马体中的铝含量依次出现最大幅度的增加。对照动物和实验动物的脑灰质中未发现显著差异。由于经铝处理动物的脑组织在所有测定组织中铝含量最低，因此似乎存在部分血脑屏障阻止铝进入。
