Ali Hassam, Waqar Syed Hamza Bin, Majeed Marwan, Sehar Alina, Mumtaz Aqsa
Department of Internal Medicine, East Carolina University/Vidant Medical Center, Greenville, NC, USA.
Department of Internal Medicine, State University of New York (SUNY) Downstate Medical Center, Brooklyn, NY, USA.
Encephalitis. 2022 Jul;2(3):83-88. doi: 10.47936/encephalitis.2022.00017. Epub 2022 Apr 28.
Posttransplant lymphoproliferative disorders (PTLDs) are potentially life-threatening complications of chronic immunosuppression in patients who receive solid organ transplants or allogeneic hematopoietic cell transplantation. Most PTLD cases are associated with Epstein-Barr virus (EBV) serology, and their incidence is typically higher in the first year of transplantation. Isolated EBV-positive diffuse large-cell B-cell lymphoma in the renal transplant setting has rarely been reported. Isolated EBV-positive primary central nervous system lymphoma (PCNSL) is rare, even in renal transplant patients with chronic immunosuppression. We report a case of frontal lobe EBV-positive PCNSL in a renal transplant patient who presented with left-sided weakness and was later treated with a consolidated chemotherapeutic regimen without concurrent radiotherapy.
移植后淋巴细胞增生性疾病（PTLDs）是接受实体器官移植或异基因造血细胞移植患者慢性免疫抑制的潜在危及生命的并发症。大多数PTLD病例与EB病毒（EBV）血清学相关，其发病率通常在移植的第一年较高。肾移植环境中孤立的EBV阳性弥漫性大细胞B细胞淋巴瘤很少被报道。孤立的EBV阳性原发性中枢神经系统淋巴瘤（PCNSL）很罕见，即使在慢性免疫抑制的肾移植患者中也是如此。我们报告一例肾移植患者发生额叶EBV阳性PCNSL，该患者表现为左侧肢体无力，随后接受了巩固化疗方案治疗，未同时进行放疗。
