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癫痫与脑炎中的远程医疗:韩国以往的研究及适应症指南

Telemedicine in epilepsy and encephalitis: previous research and indication guidelines in Korea.

作者信息

Jang Yoonhyuk, Moon Jangsup, Lee Soon-Tae, Lee Sang Kun, Chu Kon

机构信息

Department of Neurology, Laboratory for Neurotherapeutics, Comprehensive Epilepsy Center, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Department of Genomic Medicine, Seoul National University Hospital, Seoul, Korea.

出版信息

Encephalitis. 2022 Jul;2(3):65-72. doi: 10.47936/encephalitis.2022.00024. Epub 2022 Jun 20.

DOI:10.47936/encephalitis.2022.00024
PMID:37469460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10295915/
Abstract

Telemedicine is an emerging field of medicine that has become more important during the coronavirus disease 2019 (COVID-19) pandemic era and is being studied actively in various medical fields. In neurology, the introduction of telemedicine is accelerating worldwide under the label of teleneurology. So far, few studies have been conducted on telemedicine for patients with epilepsy. In nonmetropolitan areas, video-based clinics have been demonstrated to be effective for seizure control, and smartphone-based diagnosis has also been confirmed to be accurate. Indeed, after the onset of the COVID-19 pandemic, telemedicine has been used to treat patients with epilepsy around the world. Few studies have examined the use of telemedicine for patients with autoimmune encephalitis. One showed that telephone-based evaluation is sufficient to assess the cognitive reserve of leucine-rich glioma inactivated-1-antibody encephalitis patients, thereby diagnosing their dementia. Telephone-based outpatient clinics are temporarily permitted under Korean medical law, and telemedicine can be attempted for clinically stable patients with epilepsy in Korea. In addition, patients with autoimmune encephalitis in stable or improving status may also be candidates for treatment with telemedicine. This review presents evidence for the safety and efficacy of telemedicine to treat epilepsy and encephalitis patients and discusses indication guidelines. Based on our literature review and current Korean medical law, we suggest tentative guidelines for telemedicine in the fields of epilepsy and autoimmune encephalitis.

摘要

远程医疗是医学领域的一个新兴领域,在2019冠状病毒病(COVID-19)大流行期间变得更加重要,目前正在各个医学领域积极开展研究。在神经病学领域,远程医疗的引入正在以远程神经病学的名义在全球范围内加速推进。到目前为止,针对癫痫患者的远程医疗研究较少。在非大都市地区,基于视频的诊所已被证明对癫痫发作控制有效,基于智能手机的诊断也已被证实准确无误。事实上,自COVID-19大流行开始以来,远程医疗已被用于治疗世界各地的癫痫患者。针对自身免疫性脑炎患者使用远程医疗的研究很少。一项研究表明,基于电话的评估足以评估富含亮氨酸的胶质瘤失活-1抗体脑炎患者的认知储备,从而诊断其痴呆症。根据韩国医学法律,暂时允许开设基于电话的门诊诊所,在韩国,对于临床稳定的癫痫患者可以尝试使用远程医疗。此外,病情稳定或正在改善的自身免疫性脑炎患者也可能是远程医疗治疗的候选对象。本综述提供了远程医疗治疗癫痫和脑炎患者的安全性和有效性的证据,并讨论了适应症指南。基于我们的文献综述和韩国现行医学法律,我们提出了癫痫和自身免疫性脑炎领域远程医疗的暂行指南。

相似文献

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Telemedicine in epilepsy and encephalitis: previous research and indication guidelines in Korea.癫痫与脑炎中的远程医疗:韩国以往的研究及适应症指南
Encephalitis. 2022 Jul;2(3):65-72. doi: 10.47936/encephalitis.2022.00024. Epub 2022 Jun 20.
2
Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study.用于评估非住院轻中度 COVID-19 患者肠道微生物组调节的自然史和影响的虚拟化临床研究:一项随机、开放标签、前瞻性研究,平行组研究评估 KB109 对肠道微生物组结构和功能的生理影响:一项随机对照研究方案的结构化总结。
Trials. 2021 Apr 2;22(1):245. doi: 10.1186/s13063-021-05157-0.
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Telemedicine in epilepsy management during the coronavirus disease 2019 pandemic.新冠疫情期间癫痫管理中的远程医疗。
Pediatr Int. 2022 Jan;64(1):e14972. doi: 10.1111/ped.14972.
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Telemedicine in neurology: current evidence.神经病学中的远程医疗:当前证据
Arq Neuropsiquiatr. 2020 Dec;78(12):818-826. doi: 10.1590/0004-282X20200131.
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Observations in a Virtual Telephone and WhatsApp Video-Enabled Neurology Clinic During Lockdown in Varanasi, India - A Preliminary Report.在印度瓦拉纳西封锁期间,虚拟电话和 WhatsApp 视频神经科诊所的观察 - 初步报告。
Neurol India. 2021 Sep-Oct;69(5):1234-1240. doi: 10.4103/0028-3886.329546.
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COVID-19 pandemic influence on epilepsy course in pediatric patients.COVID-19 大流行对儿科癫痫患者病程的影响。
Epilepsy Behav. 2022 Apr;129:108581. doi: 10.1016/j.yebeh.2022.108581. Epub 2022 Jan 24.
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Autoimmune epilepsy in children: case series and proposed guidelines for identification.儿童自身免疫性癫痫:病例系列研究与识别建议
Epilepsia. 2013 Jun;54(6):1036-45. doi: 10.1111/epi.12142. Epub 2013 Mar 28.
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Feasibility and effectiveness of teleconsultation in children with epilepsy amidst the ongoing COVID-19 pandemic in a resource-limited country.在资源有限的国家,在持续的 COVID-19 大流行期间,远程咨询在儿童癫痫中的可行性和有效性。
Seizure. 2020 Oct;81:29-35. doi: 10.1016/j.seizure.2020.07.013. Epub 2020 Jul 18.
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Experiences of telemedicine in neurological out-patient clinics during the COVID-19 pandemic.COVID-19 大流行期间神经科门诊的远程医疗体验。
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Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.神经疾病中的谷氨酸受体抗体:抗AMPA - GluR3抗体、抗NMDA - NR1抗体、抗NMDA - NR2A/B抗体、抗mGluR1抗体或抗mGluR5抗体存在于以下疾病患者的亚组中:癫痫、脑炎、小脑共济失调、系统性红斑狼疮(SLE)和神经精神性SLE、干燥综合征、精神分裂症、躁狂症或中风。这些自身免疫性抗谷氨酸受体抗体可在少数脑区与神经元结合,激活谷氨酸受体,降低谷氨酸受体的表达,损害谷氨酸诱导的信号传导和功能,激活血脑屏障内皮细胞,杀死神经元,损伤大脑,在动物模型中诱发行为/精神/认知异常和共济失调,并且在一些患者中可通过免疫疗法去除或使其失活。
J Neural Transm (Vienna). 2014 Aug;121(8):1029-75. doi: 10.1007/s00702-014-1193-3. Epub 2014 Aug 1.

本文引用的文献

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Validation of Home Visual Acuity Tests for Telehealth in the COVID-19 Era.新冠疫情时期远程医疗中家庭视力检测的验证。
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Patient and Clinician Perspectives of New and Return Ambulatory Teleneurology Visits.患者及临床医生对新型及复诊门诊远程神经病学诊疗的看法。
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Assessment of Patient Preferences for Telehealth in Post-COVID-19 Pandemic Health Care.评估新冠疫情后医疗保健中患者对远程医疗的偏好。
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LGI1 antibody encephalitis: acute treatment comparisons and outcome.LGI1 抗体脑炎:急性期治疗比较和结局。
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Epilepsy care during the COVID-19 pandemic.COVID-19 大流行期间的癫痫护理。
Epilepsia. 2021 Oct;62(10):2322-2332. doi: 10.1111/epi.17045. Epub 2021 Aug 24.
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A new rapid titration protocol for lamotrigine that reduces the risk of skin rash.一种新的拉莫三嗪快速滴定方案,可降低皮疹风险。
Epilepsia Open. 2021 Jun;6(2):394-401. doi: 10.1002/epi4.12495. Epub 2021 May 7.
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The Rapid Transition to Telemedicine and Its Effect on Access to Care for Patients With Type 1 Diabetes During the COVID-19 Pandemic.COVID-19 大流行期间,1 型糖尿病患者向远程医疗的快速转变及其对医疗服务可及性的影响。
Diabetes Care. 2021 Jun;44(6):1447-1450. doi: 10.2337/dc20-2712. Epub 2021 Apr 13.
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Population pharmacokinetic model development and its relationship with adverse events of oxcarbazepine in adult patients with epilepsy.人群药代动力学模型的建立及其与成年癫痫患者奥卡西平不良反应的关系。
Sci Rep. 2021 Mar 18;11(1):6370. doi: 10.1038/s41598-021-85920-0.
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Autoimmune encephalitis: proposed best practice recommendations for diagnosis and acute management.自身免疫性脑炎:诊断和急性治疗的最佳实践建议。
J Neurol Neurosurg Psychiatry. 2021 Jul;92(7):757-768. doi: 10.1136/jnnp-2020-325300. Epub 2021 Mar 1.
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Racial and Ethnic Health Disparities Related to COVID-19.与新冠病毒相关的种族和族裔健康差异
JAMA. 2021 Feb 23;325(8):719-720. doi: 10.1001/jama.2020.26443.