软骨肉瘤患者中通过Ki67和异柠檬酸脱氢酶1（IDH1）进行的免疫组织化学分析

IMMUNOHISTOCHEMICAL ANALYSIS BY KI67 AND IDH1 IN PATIENTS WITH CHONDROSARCOMA.

作者信息

Ribeiro Marcelo Barbosa, Ibiapina Jerúsia Oliveira, Baptista André Mathias, Camargo Olavo Pires DE

机构信息

Universidade Federal do Piaui, Teresina, PI, Brazil.

Centro Universitario Unifacid, Teresina, PI, Brazil.

出版信息

Acta Ortop Bras. 2023 Jul 17;31(3):e267212. doi: 10.1590/1413-785220233103e267212. eCollection 2023.

DOI:10.1590/1413-785220233103e267212

PMID:37469494

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10353868/

Abstract

OBJECTIVE

To perform an immunohistochemical evaluation using the IDH1 and Ki67 markers in patients who underwent treatment for chondrosarcoma in a reference service center in Brazil.

METHODS

Retrospective analytical observational study using medical records of patients diagnosed with chondrosarcoma. Besides the epidemiological and clinical profile, important variables for prognosis and correlation with immunohistochemical analysis results with Ki67 and IDH1 markers were evaluated.

RESULTS

Histopathological examinations by immunohistochemistry of 56 patients were analyzed, 52% of which were women, with the age group 20-60 years being more prevalent. Grade 1 and 2 histological subtypes corresponded to most chondrosarcomas. The femur, humerus, and tibia were the most frequent anatomical sites. Most tumors (59%) were larger than 8 cm. Ki67 expression was very low (< 10%) in 98% of patients. The analysis of IDH1 was positive in 43% of the cases. The correlation between IDH1 positivity and tumor size was statistically significant, but regarding survival, we observed no significance.

CONCLUSION

Immunohistochemical analysis using IDH1 and Ki67 markers in patients with conventional chondrosarcoma is not useful for prognostic guidance.

摘要

目的

在巴西一家参考服务中心，对接受软骨肉瘤治疗的患者使用异柠檬酸脱氢酶1（IDH1）和Ki67标记物进行免疫组织化学评估。

方法

采用回顾性分析观察性研究，使用诊断为软骨肉瘤患者的病历。除了流行病学和临床特征外，还评估了预后的重要变量以及与Ki67和IDH1标记物免疫组织化学分析结果的相关性。

结果

对56例患者的免疫组织化学组织病理学检查进行了分析，其中52%为女性，20至60岁年龄组更为常见。1级和2级组织学亚型对应大多数软骨肉瘤。股骨、肱骨和胫骨是最常见的解剖部位。大多数肿瘤（59%）大于8厘米。98%的患者Ki67表达非常低（<10%）。43%的病例IDH1分析呈阳性。IDH1阳性与肿瘤大小之间的相关性具有统计学意义，但在生存方面，我们未观察到显著性差异。