Lee Juhee, Lee Han Sang, Chu Kon
Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Center for Hospital Medicine, Seoul National University Hospital, Seoul, Korea.
Encephalitis. 2022 Jan;2(1):14-18. doi: 10.47936/encephalitis.2021.00143. Epub 2021 Nov 15.
Monoclonal gammopathy of undetermined significance (MGUS) is associated with several autoimmune conditions, including central nervous system (CNS) vasculitis. Epstein-Barr virus (EBV) is a pathogen capable of triggering a systemic immune response and is involved in the occurrence of a wide range of B-cell lymphoproliferative disorders. In systemic autoimmune diseases, EBV infection is suspected to play a central role in pathogenesis. Here, we present a case that was thought to be a systemic autoimmune disease and CNS vasculitis that developed after EBV infection, demonstrating that rituximab is effective for the treatment.
意义未明的单克隆丙种球蛋白病（MGUS）与多种自身免疫性疾病相关，包括中枢神经系统（CNS）血管炎。爱泼斯坦-巴尔病毒（EBV）是一种能够引发全身免疫反应的病原体，参与多种B细胞淋巴增殖性疾病的发生。在全身性自身免疫性疾病中，EBV感染被怀疑在发病机制中起核心作用。在此，我们报告一例被认为是全身性自身免疫性疾病和EBV感染后发生的CNS血管炎的病例，证明利妥昔单抗治疗有效。
