惊厥性癫痫持续状态的管理：最新进展
Management of convulsive status epilepticus: recent updates.
作者信息
Byun Jung-Ick
机构信息
Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.
出版信息
Encephalitis. 2023 Apr;3(2):39-43. doi: 10.47936/encephalitis.2022.00087. Epub 2023 Jan 6.
Abstract
Convulsive status epilepticus (SE) is a medical emergency associated with high morbidity and mortality. Recently, clinical trials and meta-analyses investigating medical treatment of SE have been published. Benzodiazepine is well known as the first-line treatment for SE. Recent evidence suggests the equivalence of intravenous fosphenytoin, valproate, and levetiracetam for treatment of established SE. There is lack of evidence regarding treatment for refractory SE. Intravenous midazolam is commonly used, and recent evidence supports the use of ketamine. Additional studies are needed to improve the management of convulsive SE.
摘要
惊厥性癫痫持续状态（SE）是一种与高发病率和死亡率相关的医疗急症。最近，已经发表了调查SE药物治疗的临床试验和荟萃分析。苯二氮卓类药物是众所周知的SE一线治疗药物。最近的证据表明，静脉注射磷苯妥英、丙戊酸盐和左乙拉西坦在治疗已确诊的SE方面具有等效性。关于难治性SE的治疗缺乏证据。静脉注射咪达唑仑常用，最近的证据支持使用氯胺酮。需要进一步的研究来改善惊厥性SE的管理。
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2
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Epilepsia. 2022 Sep;63(9):2381-2391. doi: 10.1111/epi.17343. Epub 2022 Jul 10.
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