严重急性呼吸综合征冠状病毒2感染后髓鞘少突胶质细胞糖蛋白抗体相关脑炎：一例报告及回顾性病例分析
Myelin oligodendrocyte glycoprotein antibody-associated encephalitis after severe acute respiratory syndrome coronavirus 2 infection: a case report and retrospective case reviews.
作者信息
Lee Yoonkyung, Ahn Seon-Jae, Lee Han-Sang, Kim Yongmoo, Lee Seolah, Park Hyeyoung, Moon Jangsup, Lee Sang Kun, Chu Kon
机构信息
Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Hospital Medicine Center, Seoul National University Hospital, Seoul, Korea.
出版信息
Encephalitis. 2023 Apr;3(2):71-77. doi: 10.47936/encephalitis.2022.00129. Epub 2023 Mar 28.
Several cases of myelin oligodendrocyte glycoprotein (MOG) antibody-associated encephalitis have been reported after coronavirus disease 2019 (COVID-19). In this case, the patient presented with focal status epilepticus with impaired awareness, auditory hallucinations, and incoherent speech after COVID-19. Brain magnetic resonance imaging revealed no specific findings. Cerebrospinal fluid results showed pleocytosis and MOG antibody testing confirmed anti-MOG antibody with live cell-based fluorescence-activated cell sorting assay. The patient was diagnosed with MOG antibody-associated autoimmune encephalitis and treated with intravenous immunoglobulin, rituximab, and tocilizumab. This case occurred presumably due to auto-antibody production following COVID-19.
2019冠状病毒病（COVID-19）后已有多例髓鞘少突胶质细胞糖蛋白（MOG）抗体相关脑炎的报道。在本病例中，患者在感染COVID-19后出现伴有意识障碍、幻听和言语紊乱的局灶性癫痫持续状态。脑部磁共振成像未发现特异性表现。脑脊液检查结果显示细胞增多，基于活细胞的荧光激活细胞分选试验的MOG抗体检测证实存在抗MOG抗体。该患者被诊断为MOG抗体相关自身免疫性脑炎，并接受了静脉注射免疫球蛋白、利妥昔单抗和托珠单抗治疗。该病例可能是由于COVID-19后自身抗体产生所致。
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