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自身免疫性脑炎中的睡眠障碍

Sleep disturbances in autoimmune encephalitis.

作者信息

Koo Dae Lim

机构信息

Department of Neurology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Encephalitis. 2023 Jan;3(1):1-6. doi: 10.47936/encephalitis.2022.00073. Epub 2022 Dec 26.

Abstract

Autoimmune encephalitis is an inflammatory neurological disorder characterized by psychiatric symptoms, cognitive impairment, and focal neurological deficits or seizures. Sleep disturbances are not a major consideration in the diagnosis and treatment of patients with autoimmune encephalitis. Various types of sleep disturbances are frequent, severe, and long-lasting, which can compromise the recovery and quality of life in patients with autoimmune encephalitis. Sleep disorders in patients with autoimmune encephalitis have received limited attention, and the prevalence and pathophysiological mechanisms of sleep disorders remain unclear. Recent studies have suggested that early recognition of specific sleep disturbances may provide clues for diagnosing autoimmune encephalitis. Furthermore, early diagnosis and treatment of sleep disturbances can promote recovery and improve long-term outcomes in patients with autoimmune encephalitis. In this report, we aimed to provide a comprehensive and extensive understanding of the clinical relevance of autoimmune encephalitis and specific related sleep disorders.

摘要

自身免疫性脑炎是一种炎症性神经系统疾病,其特征为精神症状、认知障碍以及局灶性神经功能缺损或癫痫发作。睡眠障碍在自身免疫性脑炎患者的诊断和治疗中并非主要考虑因素。各种类型的睡眠障碍频繁、严重且持续时间长,这会损害自身免疫性脑炎患者的康复及生活质量。自身免疫性脑炎患者的睡眠障碍受到的关注有限,睡眠障碍的患病率及病理生理机制仍不明确。近期研究表明,早期识别特定的睡眠障碍可能为诊断自身免疫性脑炎提供线索。此外,对睡眠障碍的早期诊断和治疗可促进自身免疫性脑炎患者的康复并改善其长期预后。在本报告中,我们旨在全面、广泛地了解自身免疫性脑炎及特定相关睡眠障碍的临床相关性。

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本文引用的文献

1
Sleep disorders in autoimmune encephalitis.自身免疫性脑炎中的睡眠障碍。
Lancet Neurol. 2020 Dec;19(12):1010-1022. doi: 10.1016/S1474-4422(20)30341-0.
4
Sleep disorders in anti-NMDAR encephalitis.抗 NMDAR 脑炎中的睡眠障碍。
Neurology. 2020 Aug 11;95(6):e671-e684. doi: 10.1212/WNL.0000000000009987. Epub 2020 Jun 23.
7
Immunotherapy improves sleep and cognitive impairment in anti-IgLON5 encephalopathy.免疫疗法可改善抗IgLON5脑病患者的睡眠和认知障碍。
Neurol Neuroimmunol Neuroinflamm. 2019 May 21;6(4):e577. doi: 10.1212/NXI.0000000000000577. eCollection 2019 Jul.

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