佩罗尼氏病成纤维细胞中的细胞内胶原蛋白。

Intracellular collagen in fibroblasts of Peyronie's disease.

作者信息

Dini G, Grappone C, Del Rosso M, Lunghi F, Bartoletti R

出版信息

J Submicrosc Cytol. 1986 Jul;18(3):605-11.

Abstract

Ultrastructural study of fibrotic plaques from six patients with Peyronie's disease disclosed collagen fibrils located within smooth membrane bound cytoplasmic structures in most of the fibroblasts. These cells also contained prominent rough endoplasmic reticulum, which was dilated and filled with electron dense material, and hypertrophic Golgi structures in which occasional collagen fibrils were seen. Vacuoles containing collagen fibrils and amorphous substance or cellular detritus were also observed. Data from the present study support the hypothesis that intracytoplasmic collagen fibril formation is caused by excessive collagen synthesis by fibroblasts of Peyronie's fibromatosis.

摘要

对6例佩罗尼氏病患者纤维化斑块的超微结构研究显示，大多数成纤维细胞内的胶原纤维位于光滑膜结合的细胞质结构内。这些细胞还含有突出的粗面内质网，内质网扩张并充满电子致密物质，以及肥大的高尔基体结构，在其中偶尔可见胶原纤维。还观察到含有胶原纤维和无定形物质或细胞碎屑的液泡。本研究的数据支持这样一种假说，即细胞质内胶原纤维的形成是由佩罗尼氏纤维瘤病成纤维细胞过度合成胶原所致。