Hirano D, Takimoto Y, Yamamoto T, Hirakata H, Kawata N
Department of Urology, Nihon University School of Medicine, Surugadai Hospital, Tokyo, Japan.
Int J Urol. 1997 May;4(3):274-8. doi: 10.1111/j.1442-2042.1997.tb00188.x.
We conducted ultrastructural studies to clarify the fine structure of penile plaques and adjacent corpora cavernosa, and the causative basis for the process, in Peyronie's disease.
Penile plaques and adjacent corpora cavernosa were obtained during surgical extirpation from 5 patients with Peyronie's disease. Control tissues from the tunica albuginea and adjacent corpora cavernosa were obtained at penile amputation from 2 patients with penile cancer. Prepared tissues were examined by using electron microscopy.
Penile plaques were composed of collagen fibrils, amorphous particulate material, and fibroblasts in all patients. In 1 of 5 patients, myofibroblasts were found in the border area between the lesion and underlying structures. Smooth-muscle cells and endothelial cells resembling myofibroblasts were noted in adjacent corpora cavernosa. In this patient, the plaque progressively enlarged, and was removed within 1 year of onset of the induration.
Fibromatosis in Peyronie's disease involves both fibroblasts and myofibroblasts, which undergo sclerosis in some phase. In addition, smooth-muscle cells and endothelial cells in the adjacent corpora cavernosa may be incorporated in the fibromatosis.
我们进行了超微结构研究，以阐明佩罗尼氏病中阴茎硬结及相邻海绵体的精细结构，以及该病变过程的病因基础。
从5例佩罗尼氏病患者手术切除的标本中获取阴茎硬结及相邻海绵体组织。从2例阴茎癌患者阴茎切除标本中获取白膜及相邻海绵体的对照组织。制备好的组织用电子显微镜检查。
所有患者的阴茎硬结均由胶原纤维、无定形颗粒物质和成纤维细胞组成。5例患者中有1例在病变与深层结构的边界区域发现肌成纤维细胞。在相邻海绵体中可见类似肌成纤维细胞的平滑肌细胞和内皮细胞。该例患者硬结逐渐增大，硬结出现后1年内被切除。
佩罗尼氏病中的纤维瘤病涉及成纤维细胞和肌成纤维细胞，二者在某个阶段会发生硬化。此外，相邻海绵体中的平滑肌细胞和内皮细胞可能参与到纤维瘤病中。
