健康志愿者的睡眠剥夺与心率变异性：快速眼动和慢波睡眠剥夺的影响。
Sleep Deprivation and Heart Rate Variability in Healthy Volunteers: Effects of REM and SWS Sleep Deprivation.
机构信息
Department of Respiratory and Critical Care Medicine, The Affiliated Central Hospital of Qingdao University, Qingdao, Shandong, China.
Clinical Trial Research Center, The Affiliated Central Hospital of Qingdao University, Qingdao, Shandong, China.
出版信息
Comput Math Methods Med. 2023 Jul 11;2023:7121295. doi: 10.1155/2023/7121295. eCollection 2023.
OBJECTIVE
Using PSG-guided acute selective REM/SWS sleep deprivation in volunteers, this study examined the effects of sleep deprivation on the cardiovascular and autonomic nervous systems, as well as the relationship between cardiac neuromodulation homeostasis and cardiovascular disease.
METHODS
An experiment was conducted using 30 healthy volunteers (male : female = 1 : 1, aged 26.33 ± 4.5 years) divided into groups for sleep deprivation of SWS and REM sleep, and then, each group was crossed over for normal sleep (2 days) and repeated sleep deprivation (1 day, 3 times). During the study period, PSG and ELECTRO ECG monitoring were conducted, and five-minute frequency domain parameters and blood pressure values were measured before and after sleep deprivation.
RESULTS
Changes in VLF, LFnu, LF/HF, HF, and HFnu after SWS sleep deprivation were statistically significant ( < 0.05), but not LF ( = 0.063). Changes in VLF, LF, HF, LF/HF, LFnu, and HFnu after REM sleep deprivation were not statistically significant ( > 0.05).
CONCLUSIONS
An increase in sympathetic nerve activity results from sleep deprivation and sudden awakening from SWS sleep is associated with a greater risk of cardiovascular disease.
目的
通过 PSG 引导的急性选择性 REM/SWS 睡眠剥夺志愿者实验，研究睡眠剥夺对心血管和自主神经系统的影响，以及心脏神经调节稳态与心血管疾病的关系。
方法
将 30 名健康志愿者（男：女=1：1，年龄 26.33±4.5 岁）分为 SWS 和 REM 睡眠剥夺组，然后进行正常睡眠（2 天）和重复睡眠剥夺（1 天，3 次）交叉实验。研究期间进行 PSG 和 ELECTRO ECG 监测，在睡眠剥夺前后测量 5 分钟频域参数和血压值。
结果
SWS 睡眠剥夺后 VLF、LFnu、LF/HF、HF 和 HFnu 变化有统计学意义（<0.05），但 LF 无变化（=0.063）。REM 睡眠剥夺后 VLF、LF、HF、LF/HF、LFnu 和 HFnu 变化无统计学意义（>0.05）。
结论
睡眠剥夺会导致交感神经活动增加，而从 SWS 睡眠中突然觉醒与心血管疾病风险增加有关。
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