Chen Xiaoling, Li Wenmei
Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Front Neurosci. 2023 Jun 27;17:1154018. doi: 10.3389/fnins.2023.1154018. eCollection 2023.
patients with acute basal ganglia ischemic stroke (BGIS) show changes in local brain activity represented by the amplitude of low-frequency fluctuation (ALFF), but the time-varying characteristics of this local nerve activity are still unclear. This study aimed to investigate the abnormal time-varying local brain activity of patients with acute BGIS by using the ALFF method combined with the sliding-window approach.
In this study, 34 patients with acute BGIS with motor dysfunction and 44 healthy controls (HCs) were recruited. The dynamic amplitude of low-frequency fluctuation (dALFF) was employed to detect the alterations in brain activity induced by acute BGIS patients. A two-sample -test comparison was performed to compare the dALFF value between the two groups and a Spearman correlation analysis was conducted to assess the relationship between the local brain activity abnormalities and clinical characteristics.
Compared with HCs, the activity of neurons in the left temporal pole (TP), parahippocampal gyrus (paraHIP), middle occipital gyrus (MOG), dorsolateral superior frontal gyrus (SFGdl), medial cingulate cortex (MCC), right rectus, precuneus (PCu) and right cerebellum crus1 were significantly increased in patients with BGIS. In addition, we found that there was a negative correlation ( = -0.458, = 0.007) between the dALFF value of the right rectus and the scores of the National Institutes of Health Stroke Scale (NIHSS), and a positive correlation ( = 0.488, 0.499, < 0.05) with the scores of the Barthel Index scale (BI) and the Fugl Meyer motor function assessment (FMA). ROC analysis results demonstrated that the area under the curves (AUC) of the right rectus was 0.880, <0.001.
The pattern of intrinsic brain activity variability was altered in patients with acute BGIS compared with HCs. The abnormal dALFF variability might be a potential tool to assess motor function in patients with acute BGIS and potentially inform the diagnosis of this disease.
急性基底节区缺血性卒中（BGIS）患者表现出以低频波动幅度（ALFF）为代表的局部脑活动变化，但这种局部神经活动的时变特征仍不清楚。本研究旨在通过将ALFF方法与滑动窗口方法相结合，探讨急性BGIS患者异常的时变局部脑活动。
本研究招募了34例有运动功能障碍的急性BGIS患者和44例健康对照（HCs）。采用动态低频波动幅度（dALFF）来检测急性BGIS患者引起的脑活动变化。进行两样本t检验比较两组之间的dALFF值，并进行Spearman相关性分析以评估局部脑活动异常与临床特征之间的关系。
与HCs相比，BGIS患者左侧颞极（TP）、海马旁回（paraHIP）、枕中回（MOG）、背外侧额上回（SFGdl）、内侧扣带回皮质（MCC）、右侧直肌、楔前叶（PCu）和右侧小脑脚1的神经元活动显著增加。此外，我们发现右侧直肌的dALFF值与美国国立卫生研究院卒中量表（NIHSS）评分呈负相关（r = -0.458，P = 0.007），与巴氏指数量表（BI）评分和Fugl Meyer运动功能评估（FMA）评分呈正相关（r = 0.488，P = 0.499，P < 0.05）。ROC分析结果表明，右侧直肌的曲线下面积（AUC）为0.880，P < 0.001。
与HCs相比，急性BGIS患者的内在脑活动变异性模式发生了改变。异常的dALFF变异性可能是评估急性BGIS患者运动功能的潜在工具，并可能为该疾病的诊断提供依据。
