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低剂量白细胞介素-2作为难治性副肿瘤性神经系统综合征的一种新治疗选择：一例慢性复发性抗Ma2/Ta副肿瘤性脊髓神经根病病例

Low-dose interleukin-2 as a novel therapeutic option for refractory paraneoplastic neurologic syndrome: a case of chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy.

作者信息

Ahn Seon-Jae, Lee Han-Sang, Lee Woo-Jin, Chu Kon

机构信息

Center for Hospital Medicine, Seoul National University Hospital, Seoul, Korea.

Department of Neurology, Comprehensive Epilepsy Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Encephalitis. 2021 Jul;1(3):79-84. doi: 10.47936/encephalitis.2021.00038. Epub 2021 Apr 27.

DOI:10.47936/encephalitis.2021.00038
PMID:37469846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10295880/
Abstract

Paraneoplastic neurologic syndromes (PNS) caused by anti-Ma2/Ta antibodies have diverse presentations. Myeloradiculopathy is one anti-Ma2/Ta-associated PNS manifestation. We report the case of a patient with chronic relapsing anti-Ma2/Ta paraneoplastic myeloradiculopathy. The patient was successfully treated with low-dose human recombinant interleukin-2, despite having chronic relapsing symptoms and a refractory response to conventional immunotherapy.

摘要

由抗Ma2/Ta抗体引起的副肿瘤性神经系统综合征（PNS）有多种表现形式。脊髓神经根病是一种与抗Ma2/Ta相关的PNS表现。我们报告一例慢性复发性抗Ma2/Ta副肿瘤性脊髓神经根病患者的病例。尽管该患者有慢性复发性症状且对传统免疫疗法反应不佳，但经低剂量重组人白细胞介素-2治疗后获得成功。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/c312b824f00f/encephalitis-2021-00038f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/a1df9f43d4ee/encephalitis-2021-00038f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/5f2c8ccf0fe5/encephalitis-2021-00038f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/c312b824f00f/encephalitis-2021-00038f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/a1df9f43d4ee/encephalitis-2021-00038f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/5f2c8ccf0fe5/encephalitis-2021-00038f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f690/10295880/c312b824f00f/encephalitis-2021-00038f3.jpg

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