糖肽可延长寿命并缓解……中的帕金森病。 （原文句末不完整）
glycopetide prolong lifespan and alleviate Parkinson's disease in .
作者信息
Zheng Jingming, Luo Zhenhuan, Chiu Kin, Li Yimin, Yang Jing, Zhou Qinghua, So Kwok-Fai, Wan Qin-Li
机构信息
Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
State Key Lab of Brain and Cognitive Sciences, Department of Psychology, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
出版信息
Front Aging Neurosci. 2023 Jul 4;15:1156265. doi: 10.3389/fnagi.2023.1156265. eCollection 2023.
INTRODUCTION
glycopeptide (LbGp) is the main bioactive compound extracted from the traditional Chinese medicine. berries and has been proven to have numerous health benefits, including antioxidative, anti-inflammatory, anticancer, and cytoprotective activities. However, the antiaging effect of LbGp remains unknown.
METHODS
The lifespan and body movement of were used to evaluate the effect of LbGp on lifespan and health span. The thrashing assay was used to determine the role of LbGp in Parkinson's disease. To investigate the mechanisms of LbGp-induced antiaging effects, we analyzed changes in lifespan, movement, and the expression of longevity-related genes in a series of worm mutants after LbGp treatment.
RESULTS
We found that LbGp treatment prolonged the lifespan and health span of . Mechanistically, we found that LbGp could activate the transcription factors DAF-16/FOXO, SKN-1/Nrf2, and HSF-1, as well as the nuclear receptor DAF-12, thereby upregulating longevity-related genes to achieve lifespan extension. In addition, we found that the lifespan extension induced by LbGp partially depends on mitochondrial function. Intriguingly, LbGp also ameliorated neurodegenerative diseases such as Parkinson's disease in a DAF-16-, SKN-1-, and HSF-1-dependent manner.
CONCLUSION
Our work suggests that LbGp might be a viable candidate for the treatment and prevention of aging and age-related diseases.
引言
糖肽（LbGp）是从传统中药浆果中提取的主要生物活性化合物，已被证明具有多种健康益处，包括抗氧化、抗炎、抗癌和细胞保护活性。然而，LbGp的抗衰老作用仍不清楚。
方法
利用[具体生物名称]的寿命和身体运动来评估LbGp对寿命和健康寿命的影响。采用甩尾试验来确定LbGp在帕金森病中的作用。为了研究LbGp诱导抗衰老作用的机制，我们分析了LbGp处理后一系列蠕虫突变体的寿命、运动和长寿相关基因表达的变化。
结果
我们发现LbGp处理延长了[具体生物名称]的寿命和健康寿命。从机制上讲，我们发现LbGp可以激活转录因子DAF-16/FOXO、SKN-1/Nrf2和HSF-1，以及核受体DAF-12，从而上调长寿相关基因以实现寿命延长。此外，我们发现LbGp诱导的寿命延长部分依赖于线粒体功能。有趣的是，LbGp还以依赖DAF-16、SKN-1和HSF-1的方式改善了帕金森病等神经退行性疾病。
结论
我们的工作表明，LbGp可能是治疗和预防衰老及与年龄相关疾病的可行候选物。
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