Noble, Stevensville, Maryland, USA.
University of New Haven, West Haven, Connecticut, USA.
J Forensic Sci. 2023 Sep;68(5):1601-1614. doi: 10.1111/1556-4029.15340. Epub 2023 Jul 20.
Potent synthetic opioids including fentanyl and its analogs are frequently encountered in the field and require detection and identification by first responders to maintain the safety of drug abusers, first responders, health-care providers, and the public at large. Due to the low concentration at which these substances may be encountered and the complicating matrices within which they may be dispersed, the use of portable gas chromatography-mass spectrometry (GC-MS) for their identification in the field offers great potential value. This research established that portable GC-MS is a useful method for the detection and identification of a large number of synthetic opioids, especially fentanyl and its analogs. In this study, 250 synthetic opioids and related substances including 210 fentanyl analogs were analyzed using portable GC-MS. It was concluded that 225 of the 250 (90.0%) opioids analyzed were successfully detected onboard at the time of analysis and identified as either the substance (55.2%) or an analog (34.8%). These outcomes have equivalent benefit for the field analysis of illicit drugs due to both initiating the same subsequent actions by first responders.
包括芬太尼及其类似物在内的强效合成阿片类药物在该领域经常被发现，需要由急救人员进行检测和识别，以维护吸毒者、急救人员、医疗保健提供者和广大公众的安全。由于这些物质的浓度可能很低，而且它们可能分散在复杂的基质中，因此便携式气相色谱-质谱联用仪（GC-MS）在现场对其进行识别具有很大的潜在价值。这项研究表明，便携式 GC-MS 是一种用于检测和识别大量合成阿片类药物（特别是芬太尼及其类似物）的有效方法。在这项研究中，使用便携式 GC-MS 对 250 种合成阿片类药物和相关物质进行了分析。结果表明，在分析时，250 种阿片类药物中有 225 种（90.0%）在船上成功检测到，并被鉴定为物质（55.2%）或类似物（34.8%）。由于这些结果都可以为非法药物的现场分析提供相同的后续行动，因此对现场分析也具有同等的益处。
