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一项具有挑战性的介入手术:肺动脉高压患者经导管闭合管状动脉导管未闭

A Challenging Interventional Procedure: Transcatheter Closure of Tubular Patent Ductus Arteriosus in Patients with Pulmonary Hypertension.

作者信息

Yucel Ilker Kemal, Epcacan Serdar, Bulut Mustafa Orhan, Demir Ibrahim Halil, Surucu Murat, Yilmaz Emine Hekim, Kardas Murat, Kanlioglu Pinar, Celebi Ahmet

机构信息

Department of Pediatric Cardiology, University of Health Sciences Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Department of Pediatric Cardiology, University of Health Sciences Van Training and Research Hospital, Van, Turkey.

出版信息

Pediatr Cardiol. 2024 Dec;45(8):1636-1651. doi: 10.1007/s00246-023-03240-8. Epub 2023 Jul 20.

Abstract

Transcatheter closure of the tubular ducts remains the most challenging procedure, with higher complication rates than other types. This study evaluates the characteristics of transcatheter closure of tubular ducts with pulmonary hypertension. 73 patients with tubular ducts who underwent cardiac catheterization for transcatheter PDA closure were analyzed. The mean age and weight were 1.93 ± 2.68 years and 8.83 ± 6.14 kg, respectively. Transcatheter closure was attempted in 72 patients. Four cases (5.5%) were referred to surgery, while the procedure was completed in the remaining (94.5%). Amplatzer duct occluder (ADO) I or Cardiofix duct occluder (CDO) was the most commonly used devices. However, the use of Amplatzer vascular plug (AVP) II raised in recent years. The most common concern was aortic protrusion/stenosis in ADO I/CDO devices, but most regressed during follow-up. Iatrogenic coarctation of the aorta was observed in two with ADO I/CDO. Embolization of the device to the pulmonary artery was observed in three with CDO, AVP II, and AVP I. Significant left pulmonary artery stenosis requiring stenting developed in one after closure with an MVSDO device. Tubular ducts are highly associated with pulmonary arterial hypertension, and transcatheter closure of them is still challenging despite the developing device armamentarium. Although ADO I or similar devices are widely used, off-label devices are usually needed at increasing rates. The AVP II device is unsuitable for short tubular ducts but seems the best option for long ones.

摘要

经导管闭合管状动脉导管仍是最具挑战性的手术,其并发症发生率高于其他类型。本研究评估了合并肺动脉高压的管状动脉导管经导管闭合的特点。分析了73例因经导管闭合动脉导管未闭而接受心导管检查的管状动脉导管患者。平均年龄和体重分别为1.93±2.68岁和8.83±6.14千克。72例患者尝试进行经导管闭合。4例(5.5%)转为手术治疗,其余患者(94.5%)完成了该手术。Amplatzer动脉导管封堵器(ADO)I或Cardiofix动脉导管封堵器(CDO)是最常用的器械。然而,近年来Amplatzer血管塞(AVP)II的使用有所增加。最常见的问题是ADO I/CDO器械导致主动脉突出/狭窄,但大多数在随访期间消退。在2例使用ADO I/CDO的患者中观察到医源性主动脉缩窄。在3例使用CDO、AVP II和AVP I的患者中观察到封堵器栓塞至肺动脉。1例使用MVSDO器械闭合后出现严重的左肺动脉狭窄需要置入支架。管状动脉导管与肺动脉高压高度相关,尽管器械不断发展,但经导管闭合它们仍然具有挑战性。虽然ADO I或类似器械被广泛使用,但越来越多需要使用非标签器械。AVP II器械不适用于短管状动脉导管,但似乎是长管状动脉导管的最佳选择。

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