Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Center of Excellence in Periodontal Disease and Dental Implants, Chulalongkorn University, Bangkok, Thailand.
J Periodontol. 2024 Feb;95(2):135-145. doi: 10.1002/JPER.23-0197. Epub 2023 Aug 7.
Evidence on the efficacy of calcium sodium phosphosilicate (CSPS) and arginine dentifrices on reducing root sensitivity (RS) following non-surgical periodontal therapy (NSPT) is limited. The aim of this study was to compare the efficacy of these dentifrices in reducing RS during daily activities in patients undergoing NSPT.
Using a double-blind randomized controlled trial, CSPS, arginine, or control dentifrices were randomly assigned to 45 RS individuals following NSPT. The participants used the dentifrices 2×/day for 8 weeks. A self-reported visual analog scale (VAS) was assessed during daily activities.
Self-reported VAS scores were similar among the three groups at each time point. The with-in group analysis revealed that the arginine dentifrice reduced RS from Week 1-8 compared with baseline in response to cold. Similarly, the CSPS dentifrice reduced RS at Week 4 and 8. The CSPS and arginine dentifrices exhibited RS relief resulting from toothbrushing starting at Week 4 and 2, respectively. In response to air, RS relief was observed from Week 4 in the arginine group. The number of patients with VAS > 2 in response to cold declined at Week 2 and 4 in the CSPS and arginine groups, respectively. In response to toothbrushing, only 10% in the test groups still had RS at Week 8. In response to air, the number of RS patients only in the arginine group decreased at Week 4.
The CSPS and arginine dentifrices provided comparable RS relief during daily activities within 2-4 weeks and remained effective up to 8 weeks.
关于钙钠磷硅酸钠（CSPS）和精氨酸牙膏在非手术牙周治疗（NSPT）后减少根敏感（RS）的疗效的证据有限。本研究的目的是比较这些牙膏在 NSPT 后日常活动中减少 RS 的效果。
采用双盲随机对照试验，将 CSPS、精氨酸或对照牙膏随机分配给 45 名 RS 个体。参与者在 8 周内每天使用牙膏 2 次。在日常活动中使用自我报告的视觉模拟量表（VAS）进行评估。
在每个时间点，三组之间的自我报告 VAS 评分相似。组内分析显示，精氨酸牙膏在冷刺激下，从第 1 周到第 8 周，与基线相比，RS 降低。同样，CSPS 牙膏在第 4 周和第 8 周也降低了 RS。CSPS 和精氨酸牙膏在第 4 周和第 2 周开始刷牙时，分别显示出 RS 缓解。在空气刺激下，精氨酸组从第 4 周开始缓解 RS。对冷刺激反应 VAS>2 的患者数量在 CSPS 和精氨酸组分别在第 2 周和第 4 周下降。在刷牙刺激下，只有 10%的实验组患者在第 8 周仍有 RS。在空气刺激下，只有精氨酸组的 RS 患者数量在第 4 周减少。
CSPS 和精氨酸牙膏在 2-4 周内提供了相当的 RS 缓解，并且在 8 周内仍然有效。
