Kurganov B I
J Theor Biol. 1986 Apr 21;119(4):445-55. doi: 10.1016/s0022-5193(86)80194-1.
The notion of the "primary block" of cellular metabolism designated as "metabolic system" is introduced. Metabolic system is defined as a metabolic pathway which corresponds to the structurally ordered multienzyme complex. The complex of glycolytic enzymes which catalyzes the anaerobic reduction of glucose-6-phosphate with production of ATP may serve as an example of metabolic system (this complex does not contain hexokinase). The complex is formed on thin filaments of I-band of the muscle fibres or on the dimers of band 3 protein embedded in the erythrocyte membrane. The fixation of the multienzyme complex to the support of the biological nature provides the material basis for regulation of the metabolic system by chemical signals produced by the higher levels of metabolic control. Owing to interaction with anchor protein of the support the chemical signals exert the general control of functioning of the multienzyme complex (switching on-switching off the metabolic system). It is assumed that glycolytic system in skeletal muscles is stimulated by Ca2+ ions which interact with the anchor protein of the support (troponin C).
引入了被称为“代谢系统”的细胞代谢“初级模块”的概念。代谢系统被定义为与结构有序的多酶复合体相对应的代谢途径。催化6-磷酸葡萄糖无氧还原并产生ATP的糖酵解酶复合体可作为代谢系统的一个例子（该复合体不包含己糖激酶）。该复合体在肌纤维I带的细肌丝上形成，或在嵌入红细胞膜的带3蛋白二聚体上形成。多酶复合体固定于具有生物学性质的支持物上，为更高级代谢控制水平产生的化学信号调节代谢系统提供了物质基础。由于与支持物的锚定蛋白相互作用，化学信号对多酶复合体的功能发挥总体控制（开启-关闭代谢系统）。据推测，骨骼肌中的糖酵解系统受到与支持物的锚定蛋白（肌钙蛋白C）相互作用的Ca2+离子的刺激。
