Choi Joo-Hee, Sung Soo-Eun, Sung Minkyoung, Kang Kyung-Ku, Park Sun Hee, Kim Duyeol, Lee Sijoon
Preclinical Research Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea.
Biotoxtech, Co. Ltd., Cheongju, South Korea.
Vet Med Sci. 2025 Mar;11(2):e70242. doi: 10.1002/vms3.70242.
Undifferentiated pleomorphic sarcomas (UPSs) are tumours of mesenchymal origin typically seen in soft tissues and histologically characterized by pleomorphic tumour cell and multinucleated giant cell (MGC) infiltration. Here, we report UPS in a 23-month-old Sprague-Dawley rat, notable for the absence of MGC infiltration and the presence of mast cells. The tumour was located in the left axillary region and was assessed using haematoxylin and eosin, Masson's trichrome, and toluidine blue staining, along with immunohistochemistry. Neoplastic cells showed pleomorphism and storiform arrangement, with no MGCs, but with significant mast cell infiltration. Vimentin positivity confirmed the mesenchymal origin. The results in this case indicate a potential role of mast cells in UPS pathology and emphasize the need for further studies on their role in tumour progression.
未分化多形性肉瘤（UPSs）是间充质起源的肿瘤，通常见于软组织，组织学特征为多形性肿瘤细胞和多核巨细胞（MGC）浸润。在此，我们报告一例23月龄的斯普拉格-道利大鼠发生的UPS，其显著特征是缺乏MGC浸润且存在肥大细胞。肿瘤位于左腋窝区域，采用苏木精-伊红染色、Masson三色染色、甲苯胺蓝染色以及免疫组织化学进行评估。肿瘤细胞表现出多形性和席纹状排列，无MGC，但有大量肥大细胞浸润。波形蛋白阳性证实了其间充质起源。该病例结果表明肥大细胞在UPS病理过程中可能发挥作用，并强调有必要进一步研究它们在肿瘤进展中的作用。
