Koff W C, Fann A V
Lymphokine Res. 1986 Summer;5(3):215-21.
Human recombinant tumor necrosis factor-alpha (TNF) was found to recognize and destroy herpes simplex virus-infected cells while leaving uninfected cells unharmed, as determined by a 51Cr-release microcytotoxicity assay. In contrast, recombinant interleukins 1 and 2, alpha interferon and gamma interferon were not cytotoxic for virus-infected cells. The ability to discriminate between herpes virus-infected and uninfected cells suggests that TNF may be a beneficial antiviral agent.
通过51Cr释放微量细胞毒性试验测定发现，人重组肿瘤坏死因子-α（TNF）能够识别并破坏单纯疱疹病毒感染的细胞，而不损伤未感染的细胞。相比之下，重组白细胞介素1和2、α干扰素和γ干扰素对病毒感染的细胞没有细胞毒性。能够区分疱疹病毒感染细胞和未感染细胞表明TNF可能是一种有益的抗病毒剂。
