Ligotti Mattia E, Calabrò Anna, Accardi Giulia, Aiello Anna, Caruso Calogero, Colomba Claudia, Di Bona Danilo, Duro Giovanni, Namboodiri Aryan M, Tuttolomondo Antonino, Pandey Janardan P, Candore Giuseppina
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Transl Med UniSa. 2022 Dec 27;24(2):26-29. doi: 10.37825/2239-9747.1039. eCollection 2022.
Several studies suggest that genetic variants that influence the onset, maintenance and resolution of the immune response might be fundamental in predicting the evolution of COVID-19. In the present paper, we analysed the distribution of GM allotypes (the genetic markers of immunoglobulin γ chains) in symptomatic and asymptomatic COVID-19 patients and in healthy controls, all born and residing in Sicily. Indeed, the role played by GM allotypes in immune responses and infection control is well known. Our findings show that the GM23 allotype is significantly reduced in healthy controls. Interestingly, in a previous study, Sicilians carrying the GM23 allotype were associated with the risk of developing a symptomatic Human Cytomegalovirus infection. However, a note of caution should be considered, due to the small sample size of patients and controls.
多项研究表明，影响免疫反应的发生、维持和消退的基因变异可能是预测新冠病毒疾病（COVID-19）演变的关键因素。在本文中，我们分析了出生并居住在西西里岛的有症状和无症状COVID-19患者以及健康对照者中GM同种异型（免疫球蛋白γ链的遗传标记）的分布情况。事实上，GM同种异型在免疫反应和感染控制中所起的作用是众所周知的。我们的研究结果表明，GM23同种异型在健康对照者中显著减少。有趣的是，在先前的一项研究中，携带GM23同种异型的西西里人与出现有症状的人类巨细胞病毒感染的风险相关。然而，由于患者和对照的样本量较小，应谨慎看待这一结果。
