早孕期母体肾素-血管紧张素-醛固酮系统激活与自然妊娠和 IVF/ICSI 受孕后母体端粒长度的关系：鹿特丹围孕期队列研究。
First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort.
机构信息
Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Hypertens Pregnancy. 2023 Dec;42(1):2238086. doi: 10.1080/10641955.2023.2238086.
OBJECTIVE
To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI.
METHODS
In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA.
RESULTS
A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies.
CONCLUSION
The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.
目的
研究自然妊娠和体外受精/卵胞浆内单精子注射（IVF/ICSI）后妊娠中，肾素-血管紧张素-醛固酮系统（RAAS）激活的早孕母体决定因素与端粒长度（TL）之间的关联。
方法
在鹿特丹围孕期队列的 145 例妊娠中，于妊娠 9 周时测量母体血液中的肾素、前肾素和醛固酮浓度。于妊娠 20 周时通过 qPCR 测量 TL。
结果
发现肾素与 TL 呈显著负相关，前肾素也呈负相关但相关性减弱，而醛固酮则没有相关性。与自然妊娠相比，IVF/ICSI 后妊娠的母体 TL 明显缩短。
结论
早孕时母体肾素与母体 TL 之间的负相关，以及 IVF/ICSI 治疗后女性的 TL 比自然妊娠更短，证实了 RAAS 过度激活的作用。
Zotero 插件