Shi Tian-Hao, Dai Di, Huang Wen-Jie, Lü Bo-Dong
The Second School of Clinical Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.
Department of Urology and Andrology, The Second Hospital Affiliated to Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310005, China.
Zhonghua Nan Ke Xue. 2022 Apr;28(4):339-343.
Male infertility is one of the most common diseases in andrology. Studies show that male infertility is significantly correlated with the incidence and mortality of tumors, especially malignant tumors in the genitourinary system, such as testis cancer and prostate cancer. The relationship of male infertility with genitourinary system tumors involves various aspects, mainly including changes in chromosome mutations, epigenetic marks, hormonal imbalance, and congenital deformity. Besides, some chronic diseases are shown to be significantly associated with male infertility, and semen quality or fertility status may be biomarkers of the overall health of males. In-depth studies of the correlation between male infertility and these factors are very important for an insight into the pathogenesis and prevention of the related diseases.
男性不育是男科最常见的疾病之一。研究表明，男性不育与肿瘤尤其是泌尿生殖系统恶性肿瘤如睾丸癌和前列腺癌的发病率及死亡率显著相关。男性不育与泌尿生殖系统肿瘤的关系涉及多个方面，主要包括染色体突变、表观遗传标记、激素失衡及先天性畸形的变化。此外，一些慢性疾病被证明与男性不育显著相关，精液质量或生育状况可能是男性整体健康的生物标志物。深入研究男性不育与这些因素之间的相关性对于深入了解相关疾病的发病机制及预防非常重要。
