Wu Hui, Ning Gang, Zhou Xing
Hunan University of Chinese Medicine, Changsha, Hunan 410006, China.
Department of Andrology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China.
Zhonghua Nan Ke Xue. 2022 Jun;28(6):534-537.
Recent progress in the studies of testicular microenvironment has provided some new ideas on the diagnosis, treatment and prevention of related diseases. Testosterone, as an important androgen in men, regulates the physiological functions of males. The synthesis of testosterone is an extremely complex process, which mainly takes place in Leydig cells. However, Sertoli cells and testicular peritubular myoid cells, which constitute the testicular microenvironment, also play an essential role in the process of testosterone synthesis. This review focuses on the process of Leydig cells synthesizing testosterone and the effects of Sertoli cells and testicular peritubular myoid cells on testosterone synthesis from the perspective of testicular microenvironment, aiming to provide reference for the treatment and prevention of male diseases.
睾丸微环境研究的最新进展为相关疾病的诊断、治疗和预防提供了一些新思路。睾酮作为男性重要的雄激素，调节男性的生理功能。睾酮的合成是一个极其复杂的过程，主要发生在睾丸间质细胞中。然而，构成睾丸微环境的支持细胞和睾丸周细胞在睾酮合成过程中也起着至关重要的作用。本文从睾丸微环境的角度，着重综述睾丸间质细胞合成睾酮的过程以及支持细胞和睾丸周细胞对睾酮合成的影响，旨在为男性疾病的治疗和预防提供参考。
