大鼠脑低氧性缺氧的体内31P核磁共振研究。

An in vivo 31P NMR study of cerebral hypoxic hypoxia in rats.

作者信息

Litt L, González-Méndez R, Weinstein P R, Severinghaus J W, Hamilton W K, Shuleshko J, Murphy-Boesch J, James T L

出版信息

Magn Reson Med. 1986 Aug;3(4):619-25. doi: 10.1002/mrm.1910030414.

DOI:10.1002/mrm.1910030414

Abstract

Twenty minutes of hypoxic hypoxia in five anesthetized rats reversibly reduced cerebral PCr and pH while ATP stayed constant. Complete metabolic and neurologic recovery occurred after oxygen was restored. Careful control of physiological parameters resulted in metabolite changes that were the same, within errors, in each animal.

摘要

对五只麻醉大鼠进行20分钟的低氧性缺氧，可使大脑磷酸肌酸（PCr）和pH值可逆性降低，而三磷酸腺苷（ATP）保持恒定。恢复氧气供应后，代谢和神经功能完全恢复。对生理参数的精确控制导致每只动物体内代谢物的变化在误差范围内相同。