Dennerstein L, Burrows G
Maturitas. 1986 Jul;8(2):101-6. doi: 10.1016/0378-5122(86)90016-2.
Progestogens are increasingly being advocated as a necessary and integral part of hormone replacement therapy. Yet few studies have measured the acceptability of these regimes. One factor profoundly affecting acceptability, and thus patient compliance, is the presence of adverse psychological effects of progestogens. There have been few double-blind trials which have evaluated such effects of progestogens and compared them with the effects of oestrogen administration alone. There is some evidence of less favourable effects when certain progestogens are added to oestrogen or used alone. Whilst the literature is limited there is an indication that adverse effects of progestogens may relate to dosage, type of progestogen and individual sensitivity of women to hormone provocation of symptoms. Further studies are needed to test these hypotheses.
孕激素越来越多地被倡导作为激素替代疗法的必要组成部分。然而，很少有研究测量过这些治疗方案的可接受性。一个深刻影响可接受性，进而影响患者依从性的因素是孕激素存在不良心理影响。很少有双盲试验评估过孕激素的此类影响，并将其与单独使用雌激素的效果进行比较。有证据表明，当某些孕激素添加到雌激素中或单独使用时，效果不太理想。虽然文献有限，但有迹象表明，孕激素的不良反应可能与剂量、孕激素类型以及女性对激素引发症状的个体敏感性有关。需要进一步的研究来验证这些假设。
