Department of Biology, University of British Columbia, Okanagan Campus, 3187 University Way, Kelowna V1V 1V7, British Columbia, Canada.
Department of Biology, University of British Columbia, Okanagan Campus, 3187 University Way, Kelowna V1V 1V7, British Columbia, Canada.
Semin Immunol. 2023 Sep;69:101807. doi: 10.1016/j.smim.2023.101807. Epub 2023 Jul 19.
A complex mucus network made up of large polymers of the mucin-family glycoprotein MUC2 exists between the large intestinal microbial mass and epithelial and immune cells. This has long been understood as an innate immune defense barrier against the microbiota and other luminal threats that reinforces the barrier function of the epithelium and limits microbiota contact with the tissues. However, past and recent studies have provided new evidence of how critical the mucus network is to act as a 'liaison' between host and microbe to mediate anti-inflammatory, mutualistic interactions with the microbiota and protection from pathogens. This review summarizes historical and recent insights into the formation of the gut mucus network, how the microbes and immune system influence mucus, and in turn, how the mucus influences immune responses to the microbiota.
一个由黏蛋白家族糖蛋白 MUC2 组成的大型聚合物组成的复杂黏液网络存在于大肠微生物群与上皮细胞和免疫细胞之间。长期以来，人们一直认为这是一种针对微生物群和其他腔道威胁的先天免疫防御屏障，它增强了上皮细胞的屏障功能，并限制了微生物群与组织的接触。然而，过去和最近的研究提供了新的证据，证明黏液网络对于充当宿主和微生物之间的“联络人”，从而介导与微生物群的抗炎、共生相互作用以及防止病原体感染至关重要。本综述总结了肠道黏液网络形成的历史和最新见解，以及微生物和免疫系统如何影响黏液，反过来，黏液如何影响对微生物群的免疫反应。
