乙型肝炎病毒基因型和亚型的流行病学及临床相关性综述。

A review of epidemiology and clinical relevance of Hepatitis B virus genotypes and subgenotypes.

机构信息

Medical school, Kunming University of Science and Technology, Kunming, 650500, Yunnan Province, PR China; Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, 650032, PR China.

Department of Pulmonary and Critical Care Medicine, Yunnan Provincial Key Laboratory for Clinical Virology, Institute of Basic and Clinical Medicine, The First People's Hospital of Yunnan Province, Kunming, 650032, PR China.

出版信息

Clin Res Hepatol Gastroenterol. 2023 Aug;47(7):102180. doi: 10.1016/j.clinre.2023.102180. Epub 2023 Jul 20.

DOI:10.1016/j.clinre.2023.102180

PMID:37479136

Abstract

BACKGROUND

Hepatitis B virus (HBV) infection is a global public health burden, affecting nearly 300 million people around the world. Due to HBV population is considered to be represented as a viral quasispecies with genetic diversity, some reports showed that different genotypes of HBV have different viral effects, though the emergence of antiviral drugs that effectively inhibit viral replication, however, HBV infection has still not been eradicated and further research is needed.

SUMMARY

HBV has been classified into at least ten genotypes (A-J) and more than 40 subgenotypes based on an intergroup or intragroup nucleotide difference across the whole genome, respectively. Inter genotypic recombinants were also observed during the HBV evolution. HBV genotypes and subgenotypes have distinct ethno-geographical distributions, as well as evident differences in their biological characteristics. HBV genotypes and subgenotypes also have close association with disease severity, long-term clinical outcomes, and response to antiviral therapy.

KEYMESSAGES

In this review, we up-dated the epidemiological characteristics, clinical features and prognosis of HBV infection with dissimilar genotype/subgenotypes, to better understanding and developing individualized prevention and treatment strategies.

摘要

背景

乙型肝炎病毒 (HBV) 感染是一个全球性的公共卫生负担，影响着全球近 3 亿人。由于 HBV 人群被认为代表着具有遗传多样性的病毒准种，一些报道表明，HBV 的不同基因型具有不同的病毒效应，尽管出现了有效抑制病毒复制的抗病毒药物，但 HBV 感染仍未被根除，需要进一步研究。

摘要

HBV 根据整个基因组中外群或内群核苷酸差异，已被分为至少 10 个基因型 (A-J) 和 40 多个亚型。在 HBV 进化过程中也观察到了基因型间重组。HBV 基因型和亚型具有不同的种族地理分布，以及在生物学特性上有明显的差异。HBV 基因型和亚型也与疾病严重程度、长期临床结局和抗病毒治疗反应密切相关。