School of Medicine, Nankai University, Tianjin, China.
School of Medicine, Nankai University, Tianjin, China.
Biochem Biophys Res Commun. 2023 Oct 1;675:170-176. doi: 10.1016/j.bbrc.2023.07.024. Epub 2023 Jul 18.
Aerobic glycolysis preferentially exists in many cancer cells. LMO2 is an adaptor protein ubiquitously expressed in many epithelia and their malignancies, and it mediates broad-spectrum protein interactions. In this study, results showed that LMO2 directly interacted with glycolytic enzymes PGK1, PGAM1 and LDHA/LDHB, attenuated the glycolytic metabolism flow characterized by decreased glucose intake, ATP production and lactic acid excretion in lung and breast cancer cells, and was positively associated with of CD8 T-lymphocyte infiltration in the tumor microenvironment. These findings reveal a novel role of LMO2 on modulating glycolysis in tumor cells and cytotoxic T-lymphocyte infiltration in the tumor microenvironment, which expands our knowledge of LMO2 in the field of solid tumors.
有氧糖酵解优先存在于许多癌细胞中。LMO2 是一种在许多上皮细胞及其恶性肿瘤中广泛表达的衔接蛋白，它介导广谱的蛋白质相互作用。在这项研究中，结果表明 LMO2 直接与糖酵解酶 PGK1、PGAM1 和 LDHA/LDHB 相互作用，减弱了肺癌和乳腺癌细胞中以葡萄糖摄取、ATP 产生和乳酸排泄减少为特征的糖酵解代谢流，并且与肿瘤微环境中 CD8 T 淋巴细胞浸润呈正相关。这些发现揭示了 LMO2 在调节肿瘤细胞糖酵解和肿瘤微环境中细胞毒性 T 淋巴细胞浸润中的新作用，这扩展了我们对 LMO2 在实体肿瘤领域的认识。
