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LMO2对泛癌中CD8 T淋巴细胞浸润的指示作用分析。

Analysis of the effect of LMO2 on indicating CD8 T-lymphocyte infiltration in pan-cancers.

作者信息

Yu Yanhong, Yuan Mei, Zhang Zhao, Wang Dan, Sun Wei

机构信息

School of Medicine, Nankai University, No.94, Weijin Road, Tianjin, 300071, China.

Department of Pharmacy, The Nankai University affiliated Beichen Hospital, No.7, Beiyi Road, Tianjin, 300134, China.

出版信息

Biochem Biophys Rep. 2024 Dec 1;41:101890. doi: 10.1016/j.bbrep.2024.101890. eCollection 2025 Mar.

DOI:10.1016/j.bbrep.2024.101890
PMID:39686960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647632/
Abstract

LMO2 is a critical factor in hematopoiesis but widely expressed in kinds of epithelia and solid tumors as well, and it has been demonstrated that increased LMO2 level in some tumor cells exhibits an effect on promoting CD8 T-lymphocyte infiltration in tumor microenvironment. Herein we expanded the investigation of such effect in pan-cancer spectrum, and the transcriptome data analysis revealed extensively positive associations between LMO2 and CD8 T-lymphocyte infiltration in pan-cancers. Meanwhile, tissue staining revealed variable expression level and consistently cytosolic localization of LMO2 in different tissues and their tumor counterparts, and further indicated that high LMO2 expression in malignant cells was strongly associated with positive CD8 T-lymphocyte infiltration selectively in digestive tract, breast and kidney tumors. Taken together, this study depicted an overall view of LMO2 functional linkage with tumor immunology in pan-cancers and provided novel insight of LMO2 significance in the field of tumor immune therapy.

摘要

LMO2是造血过程中的一个关键因子，但也广泛表达于各种上皮组织和实体瘤中，并且已经证明，某些肿瘤细胞中LMO2水平的升高对促进肿瘤微环境中CD8 T淋巴细胞浸润具有作用。在此，我们在泛癌谱中扩展了对这种作用的研究，转录组数据分析显示，在泛癌中LMO2与CD8 T淋巴细胞浸润之间广泛存在正相关。同时，组织染色显示LMO2在不同组织及其肿瘤对应组织中的表达水平各异且始终定位于细胞质，进一步表明恶性细胞中LMO2的高表达与消化道、乳腺和肾肿瘤中CD8 T淋巴细胞的阳性浸润密切相关。综上所述，本研究描绘了LMO2在泛癌中与肿瘤免疫学功能联系的整体图景，并为LMO2在肿瘤免疫治疗领域的意义提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/3b251d5ee3a4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/8a3eff6b558f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/c1097442a5f1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/04743325c11d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/a92c5d471f8d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/3b251d5ee3a4/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/8a3eff6b558f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/c1097442a5f1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/04743325c11d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/a92c5d471f8d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e579/11647632/3b251d5ee3a4/gr4.jpg

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本文引用的文献

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Assessment of stromal tumor-infiltrating lymphocytes in neoadjuvant chemotherapy for invasive breast carcinoma: Predictive insights across molecular subtypes.浸润性乳腺癌新辅助化疗中基质肿瘤浸润淋巴细胞的评估：跨分子亚型的预测性见解
Pathol Res Pract. 2024 Aug;260:155382. doi: 10.1016/j.prp.2024.155382. Epub 2024 May 29.
2
Tumor-infiltrating lymphocytes in oral cavity squamous cell carcinoma and its association with clinicopathological parameters.口腔鳞状细胞癌中的肿瘤浸润淋巴细胞及其与临床病理参数的关系。
Pathol Res Pract. 2023 Nov;251:154882. doi: 10.1016/j.prp.2023.154882. Epub 2023 Oct 11.
3
LMO2 attenuates glycolytic metabolism and facilitates cytotoxic T-lymphocyte infiltration in the tumor environment of lung and breast cancers.
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Biochem Biophys Res Commun. 2023 Oct 1;675:170-176. doi: 10.1016/j.bbrc.2023.07.024. Epub 2023 Jul 18.
4
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Biochem Biophys Rep. 2022 Dec 10;33:101406. doi: 10.1016/j.bbrep.2022.101406. eCollection 2023 Mar.
5
Identification of a minority population of LMO2 breast cancer cells that integrate into the vasculature and initiate metastasis.鉴定出一小部分 LMO2 乳腺癌细胞能够整合到血管中并引发转移。
Sci Adv. 2022 Nov 11;8(45):eabm3548. doi: 10.1126/sciadv.abm3548. Epub 2022 Nov 9.
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A comprehensive analysis of LMO2 pathogenic regulatory profile during T-lineage development and leukemic transformation.全面分析 LMO2 在 T 细胞系发育和白血病转化过程中的致病调控特征。
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