Wang Lei, Chen Weitian, Qian Yurui, So Tiffany Y
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
Phys Med. 2023 Aug;112:102641. doi: 10.1016/j.ejmp.2023.102641. Epub 2023 Jul 20.
T1rho imaging is a promising MRI technique for imaging of brain disease. This study aimed to assess the repeatability of quantitative T1rho imaging in the normal brain grey and white matter.
The study prospectively recruited 30 healthy volunteers without a history of neurological diseases or brain injury, and T1rho was performed and quantified from three imaging sessions. Repeat measures analysis of variance (ANOVA) and within-subject coefficients of variation (wCoV) was used to detect differences in T1rho values between the three scans.
The results showed low wCoVs of less than 4.3% (range 0.92-4.27%) across all the brain structures. No significant differences were observed in T1rho measurement between the three scans (p > 0.05). The amygdala and hippocampus showed the highest T1rho values of 91.79 ± 2.55 msec and 91.07 ± 2.11 msec respectively, and the palladium and putamen had the lowest values of 67.60 ± 1.84 msec and 71.83 ± 1.85 msec respectively.
T1rho shows high test-retest repeatability for whole brain imaging in serial imaging sessions, indicating it to be a reliable sequence for quantitative brain imaging.
T1rho成像技术是一种很有前景的用于脑部疾病成像的磁共振成像（MRI）技术。本研究旨在评估定量T1rho成像在正常脑灰质和白质中的可重复性。
本研究前瞻性招募了30名无神经疾病或脑损伤病史的健康志愿者，并在三个成像时段进行T1rho成像及定量分析。采用重复测量方差分析（ANOVA）和受试者内变异系数（wCoV）来检测三次扫描之间T1rho值的差异。
结果显示，所有脑结构的wCoV均低于4.3%（范围为0.92 - 4.27%）。三次扫描之间的T1rho测量值无显著差异（p > 0.05）。杏仁核和海马体的T1rho值最高，分别为91.79 ± 2.55毫秒和91.07 ± 2.11毫秒，而苍白球和壳核的值最低，分别为67.60 ± 1.84毫秒和71.83 ± 1.85毫秒。
T1rho在连续成像时段的全脑成像中显示出较高的重测可重复性，表明它是一种可靠的定量脑成像序列。
