Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture and Rural Affairs, Institute of Agro-Product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China.
Ningbo Customs Technology Center, Ningbo, 315048, China.
Environ Sci Pollut Res Int. 2023 Aug;30(40):91945-91955. doi: 10.1007/s11356-023-28813-1. Epub 2023 Jul 22.
Bioaccessibility (BA) is a crucial factor for evaluating the absorption of pollutants in the human digestion system, which is of vital importance for risk assessment of pollutants via food intake. Multi-pesticides were detected in Dendrobium officinale Kimura et Migo (D. officinale), a popular dual-use plant with both botanical medicine and food applications. Nevertheless, the BA of pesticides in D. officinale remains unknown, restricting its market size. Herein, the BA of 19 pesticides with varying properties was evaluated by using an in vitro digestion model, showing BA values between 27.4 and 96.8%. The BA was controlled by the hydrophobicity and water solubility of pesticides, since the significant correlation between these two factors and BA values was observed. Moreover, co-ingested food ingredients could influence the BA, wherein the effect was significant for pesticides of logK values no less than 3. Lipids enhanced the BA by 9-66%, whereas proteins or carbohydrates decreased BA values by 6-28%. In particular, considering the BA, the risk quotient values were reduced by 3-73%. Clearly, this work suggested that traditional risk assessment without considering the BA would seriously overestimate the actual risk of pesticides in food.
生物可给性(BA)是评估人类消化系统中污染物吸收的一个关键因素,对于通过食物摄入评估污染物的风险至关重要。在具有药用和食用双重用途的植物铁皮石斛(Dendrobium officinale Kimura et Migo,D. officinale)中检测到了多种农药。然而,铁皮石斛中农药的生物可给性尚不清楚,限制了其市场规模。在此,通过体外消化模型评估了 19 种具有不同特性的农药的生物可给性,结果显示其生物可给性值在 27.4%至 96.8%之间。农药的生物可给性受其疏水性和水溶性控制,因为这两个因素与生物可给性值之间存在显著相关性。此外,共摄入的食物成分可能会影响生物可给性,对于 logK 值不低于 3 的农药,这种影响更为显著。脂质可使生物可给性提高 9%至 66%,而蛋白质或碳水化合物则使生物可给性降低 6%至 28%。特别是,考虑到生物可给性,风险商值降低了 3%至 73%。显然,这项工作表明,传统的风险评估如果不考虑生物可给性,将会严重高估食物中农药的实际风险。