School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, PR China.
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, PR China.
Int J Biol Macromol. 2021 Aug 1;184:1000-1013. doi: 10.1016/j.ijbiomac.2021.06.156. Epub 2021 Jun 29.
Dendrobium officinale Kimura et Migo (D. officinale) is used as herbal medicine and new food resource in China, which is nontoxic and harmless, and can be used as common food. Polysaccharide as one of the main bioactive components in D. officinale, mainly composed of glucose and mannose (Manp: Glcp = 2.01:1.00-8.82:1.00), along with galactose, xylose, arabinose, and rhamnose in different molar ratios and types of glycosidic bonds. Polysaccharides of D. officinale exhibit a variety of biological effects, including immunomodulatory, anti-tumor, gastro-protective, hypoglycemic, anti-inflammatory, hepatoprotective, and vasodilating effects. This paper presents the extraction, purification, structural characteristics, bioactivities, structure-activity relationships and analyzes gaps in the current research on D. officinale polysaccharides. In addition, based on in vitro and in vivo experiments, the possible mechanisms of bioactivities of D. officinale polysaccharides were summarized. We hope that this work may provide helpful references and promising directions for further study and development of D. officinale polysaccharides.
铁皮石斛（Dendrobium officinale Kimura et Migo）在中国被用作草药和新的食品资源，其无毒无害，可作为普通食品。多糖作为铁皮石斛中的主要生物活性成分之一，主要由葡萄糖和甘露糖（Manp: Glcp = 2.01:1.00-8.82:1.00）组成，同时还含有半乳糖、木糖、阿拉伯糖和鼠李糖，以不同的摩尔比和糖苷键类型存在。铁皮石斛多糖具有多种生物活性，包括免疫调节、抗肿瘤、胃保护、降血糖、抗炎、保肝和血管扩张作用。本文介绍了铁皮石斛多糖的提取、纯化、结构特征、生物活性、构效关系，并分析了当前铁皮石斛多糖研究中的空白。此外，基于体外和体内实验，总结了铁皮石斛多糖生物活性的可能机制。我们希望这项工作可为进一步研究和开发铁皮石斛多糖提供有价值的参考和有前景的方向。
