Endocrine Research Unit, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Endocrine Research Unit, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Arch Med Res. 2023 Sep;54(6):102856. doi: 10.1016/j.arcmed.2023.102856. Epub 2023 Jul 22.
Despite the inherent heterogeneity of the information derived from national registries, they are a useful tool to investigate the epidemiological, clinical, biochemical and treatment outcome characteristics of low prevalence conditions such as acromegaly. Although the information provided by single-center experiences is more homogeneous, these studies usually comprise a limited number of patients and thus, frequently lack statistical power.
Registry-based Information regarding the epidemiology, clinical presentation, biochemical and imaging diagnosis, as well as therapeutic outcome and mortality in acromegaly is critically analyzed.
By gathering data from multiple centers in a specific Country, these registries generate important insights into the real-life behavior of this condition, that should be considered, both, in international consensus meetings and in the design of local, Country-specific diagnostic and therapeutic strategies.
尽管国家注册中心所提供的信息存在固有的异质性，但它们是一种有用的工具，可以用于研究肢端肥大症等低流行疾病的流行病学、临床、生化和治疗结果特征。虽然单中心经验提供的信息更加同质，但这些研究通常包含有限数量的患者，因此经常缺乏统计学效力。
对肢端肥大症的流行病学、临床表现、生化和影像学诊断，以及治疗结果和死亡率的基于注册的信息进行了批判性分析。
通过在特定国家的多个中心收集数据，这些注册中心深入了解了这种疾病的实际行为，这些信息应该在国际共识会议以及当地、特定国家的诊断和治疗策略的设计中得到考虑。
