RadioTransNet-SFRO, centre Antoine-Béclère, 47, rue de la Colonie, 75013 Paris, France.
Département de radiothérapie, centre Eugène-Marquis, rue de la Bataille-Flandres-Dunkerque, CS 44229, 35042 Rennes cedex, France; Inserm, LTSI-UMR 1099, université de Rennes, 35000 Rennes, France.
Cancer Radiother. 2023 Sep;27(6-7):499-503. doi: 10.1016/j.canrad.2023.06.019. Epub 2023 Jul 21.
The RadioTransNet project is a French initiative structuring preclinical and translational research in radiation therapy for cancer at national level. The network's activities are organized around four chosen priorities, which are: target definition, normal tissue, combined treatments and dose modelling. The subtargets linked to these four major priorities are unlimited. They include all aspects associated with fundamental radiobiology, preclinical studies, imaging, medical physics research and transversal components clearly related to these scientific areas, such as medical oncology, radio-diagnostics, nuclear medicine and cost-effectiveness considerations.
During its first phase of activity, four workshops following the consensus conference model and based on scientific and medical state of the art in radiotherapy and radiobiology were organized on the four above-mentioned objectives to identify key points. Then a road map has been defined and served as the basis for the opening in 2022 of a dedicated call, SEQ-RTH22, proposed by the French cancer national institute (INCa).
Four research projects submitted by RadioTransNet partners have been selected to be supported by INCa: the first by Professor Anne Laprie from Oncopole Claudius-Regaud and Inserm ToNic in Toulouse on neurocognition and health after pediatric irradiation, the second submitted by Fabien Milliat from IRSN aims to study decryption and targeting of endothelial cell-immune cells interactions to limit radiation-induced intestinal toxicity, the third project, submitted by Yolanda Prezado from institut Curie-CNRS on proton minibeam radiotherapy as a new approach to reduce toxicity, and the latest project proposed by R. de Crevoisier from centre Eugène-Marquis in Rennes on predictive multiscale models of head and neck radiotoxicity induced for optimized personalized radiation therapy. Topics of each of these projects are presented here.
RadioTransNet project has been launched in 2018, supported by INCa, in order to structure and promote preclinical research in oncology radiotherapy and to favor collaboration between the actors of this research. INCa relied on RadioTransNet initiatives and activities, resulting in the opening of dedicated call for projects. Beyond its first main goals, RadioTransNet network is able to help to fund the human and technical resources necessary to conduct optimal translational and preclinical research in radiation oncology.
RadioTransNet 项目是法国的一项倡议，旨在在国家层面上构建癌症放射治疗的临床前和转化研究。该网络的活动围绕四个选定的重点组织，分别是：靶标定义、正常组织、联合治疗和剂量建模。与这四个主要重点相关的子目标是无限的。它们包括与基础放射生物学、临床前研究、成像、医学物理研究以及与这些科学领域明显相关的横向组成部分相关的所有方面，例如肿瘤医学、放射诊断学、核医学和成本效益考虑。
在其活动的第一阶段，根据放射治疗和放射生物学的科学和医学现状，组织了四次遵循共识会议模式的研讨会，针对上述四个目标确定了关键点。然后制定了路线图，并作为法国癌症国家研究所（INCa）于 2022 年提出的专门呼吁（SEQ-RTH22）的基础。
RadioTransNet 合作伙伴提交的四个研究项目已被 INCa 选中支持：第一个项目由图卢兹 Oncopole Claudius-Regaud 和 Inserm ToNic 的 Anne Laprie 教授提交，研究儿科放疗后神经认知和健康问题，第二个项目由 IRSN 的 Fabien Milliat 提交，旨在研究内皮细胞-免疫细胞相互作用的解密和靶向，以限制辐射引起的肠道毒性，第三个项目由居里研究所-CNRS 的 Yolanda Prezado 提交，研究质子微束放射治疗作为减少毒性的新方法，以及最后一个项目由雷恩 Eugène-Marquis 中心的 R. de Crevoisier 教授提交，研究头颈部放射毒性的预测多尺度模型，以优化个性化放射治疗。这些项目中的每一个项目的主题都在这里介绍。
RadioTransNet 项目于 2018 年由 INCa 支持启动，旨在构建和促进肿瘤放射治疗的临床前研究，并促进该研究领域的参与者之间的合作。INCa 依赖于 RadioTransNet 的倡议和活动，促成了专门项目呼吁的开放。除了其最初的主要目标外，RadioTransNet 网络还能够帮助资助开展最佳转化和临床前放射肿瘤学研究所需的人力和技术资源。
