在新冠疫情期间，呼吸道合胞病毒的流行病学为何发生了变化？
Why has the epidemiology of RSV changed during the COVID-19 pandemic?
作者信息
Abu-Raya Bahaa, Viñeta Paramo Marina, Reicherz Frederic, Lavoie Pascal Michel
机构信息
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
British Columbia Children's Hospital Research Institute, Vancouver, Canada.
出版信息
EClinicalMedicine. 2023 Jul 6;61:102089. doi: 10.1016/j.eclinm.2023.102089. eCollection 2023 Jul.
Abstract
The coronavirus disease 2019 (COVID-19) pandemic has drastically perturbed the epidemiology of Respiratory Syncytial Virus (RSV) respiratory tract infections in children. The reasons for this are not clear. In this article, we review the current literature and critically discuss the different theories to explain why the epidemiology of RSV has changed during the COVID-19 pandemic. Proposed mechanisms include decreased viral immunity in vulnerable age groups caused by the prolonged lack of RSV circulation early in the pandemic, potential Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2)-induced immune dysregulation, viral interactions between SARS-CoV-2 and RSV, and modifications in health-seeking behaviors as well as heath systems factors. Research in viral genomics and phylogeny, and more robust immunology research is needed to guide RSV prevention and health care resource planning.
摘要
2019冠状病毒病（COVID-19）大流行极大地扰乱了儿童呼吸道合胞病毒（RSV）呼吸道感染的流行病学。其原因尚不清楚。在本文中，我们回顾了当前的文献，并批判性地讨论了不同的理论，以解释为什么RSV的流行病学在COVID-19大流行期间发生了变化。提出的机制包括在大流行早期由于RSV长期缺乏传播导致易感年龄组的病毒免疫力下降、严重急性呼吸综合征冠状病毒2（SARS-CoV-2）诱导的潜在免疫失调、SARS-CoV-2与RSV之间的病毒相互作用，以及就医行为和卫生系统因素的改变。需要进行病毒基因组学和系统发育研究，以及更有力的免疫学研究，以指导RSV预防和卫生保健资源规划。
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